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Corticosteroids and Nonsteroidal Anti-inflammatory Agents in the Sepsis Syndrome

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Sepsis

Abstract

The etiology for many of the alterations that occur in the sepsis syndrome have confounded researchers for years. Despite the great strides we have made in evaluating the role of the coagulation, complement, arachidonic acid, and other systems in the sepsis syndrome, we have not been able to define clearly the initiating event. Without a clearer understanding of the pathophysiologic mechanisms causing the changes in the sepsis syndrome, it may be unrealistic to expect major advances in improving survival with our current therapies. The present chapter will summarize some of the animal and human data concerning the use of nonsteroidal antiinflammatory agents (NSAIA) and corticosteroids in the sepsis syndrome. We have defined the sepsis syndrome as a spectrum of disease from early sepsis (a systemic response to infection) to septic shock. A more detailed review of the subject can be found elsewhere [1, 2].

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Authors
  1. C. L. Sprung
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  2. R. M. H. Schein
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  3. W. M. Long
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Editors and Affiliations

  1. Klinik für Anästhesiologie und operative Intensivmedizin, Freie Universität Berlin, Universitätsklinikum Steglitz, Hindenburgdamm 30, 1000, Berlin 45, Germany

    K. Reinhart  & K. Eyrich  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Sprung, C.L., Schein, R.M.H., Long, W.M. (1989). Corticosteroids and Nonsteroidal Anti-inflammatory Agents in the Sepsis Syndrome. In: Reinhart, K., Eyrich, K. (eds) Sepsis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83083-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-83083-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83085-3

  • Online ISBN: 978-3-642-83083-9

  • eBook Packages: Springer Book Archive

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