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Role of Respiratory Muscles in Weaning

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Update 1987

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 3))

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Abstract

In a previous study [1] we have shown that patients with chronic obstructive pulmonary disease (COPD) during acute respiratory failure had an increased inspiratory neuromuscular drive to breathe. Indeed, the latter which was assessed by measurement of tracheal occlusion pressure (P0.1) amounted to 8±1 cmH20 at the onset of the acute respiratory failure during room air breathing [1]. In normal persons, such P0.1 values are obtained for a level of minute ventilation (V̇E) of the order of 50 to 70 1/min [2]. This high inspiratory neuromuscular output will therefore impose a very high load on the respiratory muscles of these patients. Furthermore, as a result of pulmonary hyperinflation, the inspiratory muscles of these patients operate at a mechanical disadvantage. This implies that during acute respiratory failure, the activity of the respiratory muscles of COPD patients is very high and probably cannot be sustained for a prolonged period without development of inspiratory muscle fatigue.

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Authors
  1. M. Aubier
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Assistant-Director) (Assistant-Director)

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© 1987 Springer-Verlag Berlin Heidelberg

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Aubier, M. (1987). Role of Respiratory Muscles in Weaning. In: Vincent, J.L. (eds) Update 1987. Update in Intensive Care and Emergency Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83042-6_29

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  • DOI: https://doi.org/10.1007/978-3-642-83042-6_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17576-6

  • Online ISBN: 978-3-642-83042-6

  • eBook Packages: Springer Book Archive

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