Abstract
Flow and pressure in the systemic and pulmonary circulation are affected by two types of changes in airway pressure: a static type applied for a relatively long time like positive end-expiratory pressure (PEEP), and a dynamic type of rise and fall during each ventilatory cycle. In both types, the increase in airway pressure will increase intrathoracic and central venous pressure. Consequently, a decrease in venous return occurs [1–8]. However, for both types, the same rise in airway pressure will not have the same quantitative effect, because during PEEP two additional control mechanisms are involved. A lung stretch reflex is increasing the negative effects of central venous pressure on flow and arterial blood pressure [8–10], and control mechanisms elicited by baroreceptor activity are compensating for these negative effects [8, 11]. During a ventilatory cycle, the time of rise and fall in airway pressure is too short to elicit these neurogenic and humoral control mechanisms. Changes in circulation during a ventilatory cycle, therefore, will be mainly due to direct mechanical effects.
Preview
Unable to display preview. Download preview PDF.
References
Cassidy SS, Robertson CH Jr, Pierce AK, Johnson RL Jr (1978) Cardiovascular effects of positive end-expiratory pressure in dogs. J Appl Physiol 44:743–750
Fewell JE, Abendschein DR, Carlson CJ, Murray JF, Rapaport E (1980) Continuous positive-pressure ventilation decreases right and left ventricular end-diastolic volumes in the dog. Circ Res 46:125–132
Harboe S, Levang OW, Hysing ES (1979) The effect of positive end-expiratory pressure after three types of open heart surgery. Acta Anaesthesiol Scand 23:165–176
Hobelmann CF Jr, Smith DE, Virgilio RW, Shapiro AR, Peters RM (1975) Hemodynamic alterations with positive end-expiratory pressure: the contribution of the pulmonary vasculature. J Trauma 15:951–958
Qvist J, Pontoppidan H, Wilson RS, Lowenstein E, Laver MB. Hemodynamic responses to mechanical ventilation with PEEP: the effect of hypervolemia. Anesthesiology 42:45–55
Robotham JL, Lixfield W, Holland L, MacGregor D, Bromberger-Barnea B, Permutt S, Rabson JL (1980) The effects of positive end-expiratory pressure on right and left ventricular performance. Am Rev Respir Dis 121:677–683
Scharf SM, Caldini P, Ingram RH Jr Cardiovascular effects of increasing airway pressure in the dog. Am J Physiol 232 (Heart Circ Physiol 1): H35–H43
Schreuder JJ, Jansen JRC, Bogaard JM, Versprille A (1982) Hemodynamic effects of positive end-expiratory pressure applied as a ramp. J Appl Physiol 53:1239–1247
Cassidy SS, Eschenbacher WL, Johnson RL Jr (1979) Reflex cardiovascular depression during unilateral lung hyperinflation in the dog. J Clin Invest 64:620–626
Schreuder JJ, Jansen JRC, Versprille A (1984) Contribution of lung stretch depressor reflex to nonlinear fall in cardiac output during PEEP. J Appl Physiol 56:1578–1582
Schreuder JJ, Jansen JRC, Versprille A (1985) Hemodynamic effects of PEEP applied as a ramp in normo-, hyper-, and hypovolemia. J Appl Physiol 59:1178–1184
Hoffman JIE, Guz A, Charlier AA, Wilcken DEL (1965) Stroke volume in conscious dogs: effect of respiration, posture, and vascular occlusion. J Appl Physiol 20:865–877
Morgan BC, Martin WE, Hornbein TF, Crawford EW, Guntheroth WG (1966) Hemodynamic effects of intermittent positive pressure respiration. Anesthesiology 27:584–590
Nordström L (1972) On automatic ventilation. Part II: Haemodynamic effects of intermittent positive-pressure ventilation with and without an end-expiratory pause. Acta Anaesthesiol Scand (Suppl) 47:29–56
Versprille A, Jansen JRC (1985) Mean systemic filling pressure as a characteristic pressure for venous return. Pflügers Archiv 405:226–233
Versprille A, Jansen JRC, Schreuder JJ (1982) Dynamic aspects of the interaction between airway pressure and the circulation. In: Prakash O (ed) Applied Physiology in Clinical Respiratory Care, Martinus Nijhoff Publishers BV, The Hague, pp 447–463
Wong M, Escobar EE, Martinex G, Butler J, Rapaport E (1967) Effect of continuous pressure breathing on right ventricular volumes. J Appl Physiol 22:1053–1060
Guyton AC, Lindsey AW, Kaufmann BN (1955) Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180:463–468
Guyton AC, Jones CE, Coleman TG (1973) Circulatory physiology: Cardiac output and its regulation. W. B. Saunders Company, Philadelphia
Pinsky MR (1984) Instantaneous venous return curves in an intact canine preparation. J Appl Physiol: Respir Environ Excercise Physiol 56:765–771
Donald ED, Edis AJ (1971) Comparison of aortic and carotid baroreflexes in the dog. J Physiol 215:521–538
Scher AM, Young AC (1963) Servoanalysis of carotid sinus reflex effects on peripheral resistance. Circ Res 12:152–162
Hughes JMB (1977) Pulmonary circulation and fluid balance. Chapt. 5 in: Widdicombe JG (ed) Respiratory Physiology II, International Review of Physiology, vol. 14, University Park Press, Baltimore, pp. 135–185
Buda AJ, Pinksy MR, Ingels NB, Daughters GT, Stinson EB, Alderman EL (1979) Effect of intrathoracic pressure on left ventricular performance. N Engl J Med 301:453–459
Summer WR, Permutt S, Sagawa K, Shoukas AA, Bromberger-Barnea B (1979) Effects of spontaneous respiration on canine left ventricular function. Circ Res 45:719–728
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Versprille, A. (1987). Pulmonary Blood Flow and Blood Volume During Positive Pressure Ventilation. In: Vincent, J.L. (eds) Update 1987. Update in Intensive Care and Emergency Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83042-6_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-83042-6_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17576-6
Online ISBN: 978-3-642-83042-6
eBook Packages: Springer Book Archive