Abnormal Metabolic Control in Septic Multiple Organ Failure
The usual characterization of sepsis is that it is a disease process caused by infectious organisms. However, recent evidence suggests that sepsis is rather an acquired disease of intermediary metabolism induced by the host response to invasion by infectious agents.The characteristics and the magnitude of this metabolic disorder are not specific for particular infectious agents, but occur with bacterial, fungal and viral organisms. The metabolic dysfunction which is initiated by sepsis induces a shift in the pattern of physiologic abnormalities and dynamic metabolic interrelations which are involved in the regulation of energetic substrate flux between skeletal muscle, liver and adipose tissue. This altered regulation modifies the normal balance of control by neuro and endocrine mechanisms.
KeywordsHyperdynamic State Muscle Proteolysis Septic Process Organ Clearance Septic Response
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