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The Role of Prostaglandins in ARDS

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Update 1987

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 3))

Abstract

Biologically active metabolites of arachidonic acid have been implicated as causative agents of the Adult Respiratory Distress Syndrome (ARDS). As seen in Figure 1, arachidonic acid, generated from membrane phospholipids, is metabolized via the cyclo-oxygenase pathway to the classic prostaglandins and thromboxane A2, and via the 5-lipoxygenase pathway to the leukotrienes. Of these substances, thromboxane A2, prostacyclin, prostaglandin E2 and leukotrienes B4, C4, D4, and E4 appear to be most significant in the pathophysiology of ARDS. The purpose of this review is to summarize the current knowledge of these eicosanoids and their involvement in ARDS.

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Authors
  1. G. J. Slotman
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Assistant-Director) (Assistant-Director)

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© 1987 Springer-Verlag Berlin Heidelberg

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Slotman, G.J. (1987). The Role of Prostaglandins in ARDS. In: Vincent, J.L. (eds) Update 1987. Update in Intensive Care and Emergency Medicine, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83042-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-83042-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17576-6

  • Online ISBN: 978-3-642-83042-6

  • eBook Packages: Springer Book Archive

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