Abstract
The exocrine pancreas is a highly active site of protein synthesis. Most of the proteins consist of digestive enzymes destined for export from the acinar cell and in normal human pancreatic juice, as in other species, they constitute about 90% of the total proteins of the juice [1]. In the remaining 10% we identified serum proteins accounting for 3% of the total, and other proteins to a very low amount in normal juice but specifically increased in chronic pancreatitis (as observed for lactoferrin and lysosomal enzymes [2]).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Guy O, Figarella C (1981) The proteins of human external secretion. Scand J Gastroenterol 16:59–61
Figarella C (1980) La lactoferrine dans les pancréatites chroniques calcifiantes. Hypothèse pour le rôle biologique de la protéine. Gastroenterol Clin Biol 4:631–635
Figarella C, De Caro A, Oi I, Sahel J (1978) Lipase activity in blood following endoscopic pancreatography: demonstration of its pancreatic origin and existence of ductal or acinovenous pathways in man. Scand J Gastroenterol 13:393–399
Misczuk-Jamska B, Guy O, Figarella C (1983) α1-Proteinase inhibitor in pure human pancreatic juice. Characterization of a complexed form in patients with chronic calcifying pancreatitis and its significance. Hoppe Seyler’s Z Physiol Chem 364:1597–1601
Figarella C, Amouric M, Guy-Crotte O (1984) Proteolysis of human trypsinogen 1. Pathogenic implication in chronic pancreatitis. Biochem Biophys Res Commun 118:154–161
Guy-Crotte O, Amouric M, Figarella C (1984) Characterization and N-terminal sequence of a degradation product of 14000 molecular weight isolated from human pancreatic juice. Biochem Biophys Res Commun 125:516–523
Greenbaum LM, Hirschkowitz A, Shoichet I (1959) The activation of trypsinogen by cathepsin B. J Biol Chem 234:2885–2890
Steer M, Meldolesi J, Figarella C (1984) Pancreatitis. The role of lysosomes. Dig Dis Sci 29:934–938
Koike H, Steer ML, Meldolesi J (1982) Pancreatic effects of ethionine: blockade of exo-cytosis and appearance of crinophagy and autophagy precede cellular necrosis. Am J Physiol 242: G 297–307
Watanabe O, Baccino FM, Steer ML, Meldolesi J (1984) Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis. Am J Physiol 246: G 457–467
Tasso F, Stemmelin N, Clop J, Cros RC, Durbec JP, Sarles H (1973) Comparative morphometry study of the human pancreas in its normal state and in primary chronic calcifying pancreatitis. Biomedicine 19:1–11
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Figarella, C., Amouric, M., Guy-Crotte, O. (1987). Enzyme Activation and Liberation: Intracellular/Extracellular Events. In: Beger, H.G., Büchler, M. (eds) Acute Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83027-3_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-83027-3_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83029-7
Online ISBN: 978-3-642-83027-3
eBook Packages: Springer Book Archive