Abstract
The pancreatic duct acts like a semipermeable membrane, restricting the passage of various molecules through it in both directions. Among other factors, the size of the molecule determines the ease with which that passage takes place. Relatively small particles, like bicarbonate and chloride ions, diffuse through the duct wall easily. Normally, large molecules like the pancreatic digestive enzymes are contained within the duct almost entirely.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Reber HA, Roberts C, Way LW (1979) The pancreatic duct mucosal barrier. Am J Surg 137:128–134
Farmer RC, Maslin SC, Reber HA (1982) Effects of acute ethanol and aspirin ingestion on pancreatic duct permeability to macromolecules. Gastroenterology 82:1053
Reber HA, Farmer RC, Maslin SC (1982) Effects of bile on the permeability of the pancreatic duct to macromolecules. Gastroenterology 82:1156
Farmer RC, Tweedie J, Maslin SC, Reber HA, Adler G, Kern H (1984) Effects of bile salts on permeability and morphology of main pancreatic duct in cats. Dig Dis Sci 29:740–751
Farmer RC, Maslin SC, Reber HA (1983) Acute pancreatitis — role of duct permeability. Surg Forum 34:224–227
Reber HA, et al. (1984) A model of hemorrhagic pancreatitis: the role of 16–16 dimethyl PGE2 (PG). Gastroenterology 86:1295
Watanabe T, Steer ML (1980) Protective effects of PGE2 on diet induced acute pancreatitis in mice. Gastroenterology 78:777–781
Standfield NJ, Kakkar VV (1983) Prostaglandins and acute pancreatitis — experimental and clinical studies. Br J Surg 70:573 — 576
Coelle EF, Adham N, Elashoff J, Lewin K, Taylor IL (1983) Effects of prostaglandin and indomethacin on diet-induced acute pancreatitis in mice. Gastroenterology 85:1307–1312
Lankisch PG, Göke B, Kunze H, Otto J, Winckler K (1983) Does PGE2 have a beneficial effect on acute experimental pancreatitis in the rat? Hepatogastroenterology 36:148–150
Lankisch PG, Koop H, Winckler K, Kunze H, Vogt W (1978) Indomethacin treatment of acute experimental pancreatitis in the rat. Scand J Gastroenterol 13:629–633
Olazabal A (1983) Effect of prostaglandin E2 and I2 and of indomethacin on deoxycholic acid-induced damage to the rat bile-pancreatic duct. Gastroenterology 84:928–934
Arfors KE, Rutili G, Svensjo E (1979) Microvascular transport of macromolecules in normal and inflammatory conditions. Acta Physiol Scand [Suppl] 462:93–103
Homma T, Malik KU (1982) Effect of prostaglandins on pancreatic circulation in anesthetized dogs. J Pharmacol Exp Ther 222:623–628
Saunders RN, Moser CA (1972) Changes in vascular resistance induced by prostaglandins E2 and F2 in the isolated rat pancreas. Arch Int Pharmacodyn 197:86–92
Wedgwood KR, Farmer RC, Reber HA (1986) A model of hemorrhagic pancreatitis in cats — the role of 16, 16-dimethyl prostaglandin E2. Gastroenterology 90:32–39
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Reber, H.A. (1987). Changes in Duct and Vascular Permeability: The Key to the Development of Acute Pancreatitis. In: Beger, H.G., Büchler, M. (eds) Acute Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83027-3_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-83027-3_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83029-7
Online ISBN: 978-3-642-83027-3
eBook Packages: Springer Book Archive