Substitution of Pancreatic Enzymes: Basic Information by In Vitro Investigations

  • M. Otte
  • P. Ridder


Substitution of pancreatic enzymes is necessary in only few patients. Not until the secretory capacity has been reduced to about 10%, when maldigestion usually becomes manifest, does steatorrhoea appear [1, 7]. Such extensive insufficiency of the pancreas normally develops in patients with advanced chronic pancreatitis, cystic fibrosis, after resective operations of the pancreas, and sometimes in patients with pancreatic carcinoma. Only those patients with a daily weight of faeces of more than 250 g and/or with a loss of weight, although food intake is sufficient, require treatment [8].


Enzyme Replacement Therapy Pancreatic Enzyme Pancreatic Exocrine Insufficiency Exocrine Pancreatic Insufficiency Lipase Content 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. Otte
    • 1
  • P. Ridder
    • 1
  1. 1.Medizinische Hochschule LübeckLübeck 1Germany

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