Skip to main content
SpringerLink
Log in

Phospholipase A2 in Acute Pancreatitis

  • Chapter
Acute Pancreatitis

Abstract

Acute pancreatitis is an autodigestive disease, in which digestive enzymes produced by the pancreas destroy the gland. Opie and Meakins [29] proposed that it is trypsin that causes the tissue injury. However, it seems more probable that phospholipase A2 might be the enzyme responsible for autodigestion in acute pancreatitis [26]. Accordingly, increased catalytic activities of this enzyme [33] as well as above-normal concentrations of immunoreactive phospholipase A2 [27] have been detected in sera of patients suffering from acute pancreatitis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aho HJ, Ahola RA, Tolvanen AM, Nevalainen TJ (1983) Experimental pancreatitis in the rat. Changes in pulmonary phospholipids during sodium taurocholate-induced acute pancreatitis. Res Exp Med 182:79–84

    Article  CAS  Google Scholar 

  2. Aho HJ, Koskensalo SM-L, Nevalainen TJ (1980) Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 15:411–416

    Article  PubMed  CAS  Google Scholar 

  3. Aho HJ, Nevalainen TJ (1982) Experimental pancreatitis in the rat. Light and electron microscopical observations on early pancreatic lesions induced by intraductal injection of trypsin, phospholipase A2, lysolecithin and non-ionic detergent. Virchows Arch [Cell Pathol] 40:347–356

    Article  CAS  Google Scholar 

  4. Aho HJ, Nevalainen TJ, Aho AJ (1983) Experimental pancreatitis in the rat. Development of pancreatic necrosis, ischaemia and oedema after intraductal sodium taurocholate injection. Eur Surg Res 15:28–36

    Article  PubMed  CAS  Google Scholar 

  5. Aho HJ, Nevalainen TJ, Lindberg RLP, Aho AJ (1980) Experimental pancreatitis in the rat. The role of phospholipase A in sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 15:1027–1031

    Article  PubMed  CAS  Google Scholar 

  6. Arnesjö B (1971) The formation of lysolecithin in the rat pancreas after experimentally induced bile salt pancreatitis. Acta Chir Scand 137:351–354

    PubMed  Google Scholar 

  7. Barie PS, Tahamont MV, Blumenstock FA, Malik AB (1982) The role of neutrophils in the pathogenesis of pulmonary vascular injury after acute pancreatitis. Curr Surg 39:411–413

    PubMed  CAS  Google Scholar 

  8. van den Bosch H (1980) Intracellular phospholipases. Biochim Biophys Acta 604:191–246

    Article  PubMed  Google Scholar 

  9. Cho KS, Proulx P (1978) Uptake of lysolecithin and other lysins by rat erythrocytes. Rev Can Biol 37:219–224

    PubMed  CAS  Google Scholar 

  10. Durand S, Clemente F, Douste-Blazy L (1980) A non-secretory phospholipase A2 in the rat pancreas. Biomedicine 33:19–21

    PubMed  CAS  Google Scholar 

  11. Etienne J, Grüber A, Polonovski J (1984) Inhibitory factor of phospholipase A2 in normal human serum. Biochem Biophys Res Commun 122:1117 - 1124

    Article  PubMed  CAS  Google Scholar 

  12. Flower R (1981) Glucocorticoids, phospholipase A2 and inflammation. Trends Pharmacol Sci 2:186–188

    Article  CAS  Google Scholar 

  13. Freise J, Hagersted P, Schmid K (1983) Inhibition of phospholipase A2 by gabexate mesilate, camostate, and aprotinin. Enzyme 30:209–212

    PubMed  CAS  Google Scholar 

  14. Gilsdorf RB, Urdaneta LF, Delaney JP, Leonard AS (1967) Central nervous system influences on pancreatic secretion, sphincteric mechanisms, and blood flow and their role in the course of pancreatitis. Surgery 62:581 – 588

    PubMed  CAS  Google Scholar 

  15. Goldstein IM, Lind S, Hoffstein S, Weissmann G (1977) Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. J Exp Med 146:483–494

    Article  PubMed  CAS  Google Scholar 

  16. de Haas GH, Postema NM, Niewenhuizen W, van Deenen LLM (1968) Purification and properties of phospholipase A from porcine pancreas. Biochim Biophys Acta 159:103–117

    PubMed  Google Scholar 

  17. Haberland G, Matis P (1967) Trasylol, ein Proteinaseninhibitor bei chirurgischen und in-ternen Indikationen. Med Welt 18:1367–1376

    Google Scholar 

  18. Kimura T, Toung JK, Margolis S, Bell WR, Cameron JL (1980) Respiratory failure in acute pancreatitis: the role of free fatty acids. Surgery 87:509–513

    PubMed  CAS  Google Scholar 

  19. Kumar R, Hegde KS, Krishna B, Sharma RS (1980) Combined effect of hypoxia and cold on the phospholipid composition of lung surfactant in rats. Aviat Space Environ Med 5:459–462

    Google Scholar 

  20. Lankisch PG, Rahlf G, Koop H (1983) Pulmonary complications in fatal acute hemorrhagic pancreatitis. Dig Dis Sci 28:111–116

    Article  Google Scholar 

  21. Lefer AM (1978) Properties of cardioinhibitory factors produced in shock. Fed Proc 37:2734–2740

    PubMed  CAS  Google Scholar 

  22. Lenninger S (1977) The autonomic innervation of the exocrine pancreas. Med Clin North Am 58:1311–1318

    Google Scholar 

  23. Lombardo D, Dennis EA (1985) Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. J Biol Chem 260:7234–7240

    PubMed  CAS  Google Scholar 

  24. Miwa M, Kubota I, Ichihashi T, Motojima H, Matsumoto M (1984) Studies on phospholipase A inhibitor in blood plasma. I. Purification and characterization of phospholipase A inhibitor in bovine plasma. J Biochem 96:761–773

    PubMed  CAS  Google Scholar 

  25. Naoi M, Yagi K (1980) Modification of the reactivity of beef heart mitochondrial monoamine oxidase by phospholipases. Biochim Int 1:371 – 376

    CAS  Google Scholar 

  26. Nevalainen TJ (1980) The role of phospholipase A in acute pancreatitis. Scand J Gastroenterol 15:641–650

    Article  PubMed  CAS  Google Scholar 

  27. Nevalainen TJ, Eskola JU, Aho AJ, Havia TV, Lovgren TN-E, Näntö V (1985) Immunoreactive phospholipase A2 in acute pancreatitis and pancreatic cancer. Clin Chem 31:1116–1120

    PubMed  CAS  Google Scholar 

  28. Nevalainen TJ, Evilampi OS (1984) Presence of a phospholipase A2 inhibitor in porcine serum. J Biochem 96:1303–1305

    PubMed  CAS  Google Scholar 

  29. Opie EL, Meakins JC (1909) Data concerning the etiology and pathology of hemorrhagic necrosis of the pancreas (acute hemorrhagic pancreatitis). J Exp Med 11:561–578

    Article  PubMed  CAS  Google Scholar 

  30. Papp M, Brener JH, Nemeth EP, Fodor I, Folly G (1973) On the lysolecithin content of the pancreas in experimental acute pancreatitis. Gastroenterology 65:778 – 787

    PubMed  CAS  Google Scholar 

  31. Pieterson WA, Vidal JC, Volverk JJ, de Haas GH (1974) Zymogen-catalyzed hydrolysis of monomeric substrates and a presence of a recognition site for lipid-water interfaces in phospholipase A2. Biochemistry 13:1455–1460

    Article  PubMed  CAS  Google Scholar 

  32. Schröder T, Kinnunen PKJ, Lempinen M (1978) Xylocaine treatment in experimental pancreatitis in pigs. Scand J Gastroenterol 13:863–865

    Article  PubMed  Google Scholar 

  33. Schröder T, Kivilaakso E, Kinnunen PKJ, Lempinen M (1980) Serum phospholipase A2 in human acute pancreatitis. Scand J Gastroenterol 15:633–636

    Article  PubMed  Google Scholar 

  34. Schröder T, Lempinen M, Nordling S, Kinnunen PKJ (1981) Chlorpromazine treatment of experimental acute fulminant pancreatitis in pigs. Eur Surg Res 13:143–151

    Article  PubMed  Google Scholar 

  35. Schröder T, Somerharju P, Lempinen M (1979) Phospholipase A2 in serum and ascitic exudate in experimental acute haemorrhagic pancreatitis in pigs. Eur Surg Res 11: 172–178

    Article  PubMed  Google Scholar 

  36. Tykka H, Mahlberg K, Pantzar P, Tallberg T (1980) Phospholipase A2 inhibitors and their possible clinical use in the treatment of acute pancreatitis. Scand J Gastroenterol 15:519–528

    Article  PubMed  Google Scholar 

  37. Whelan CJ (1978) Histamine release from rat peritoneal mast cells by phospholipase A. The “activation” of phospholipase A by phospholipids. Biochem Pharmacol 27: 2115–2118

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Turku, Kiinamyllynkatu 10, SF-20520, Turku 52, Finland

    T. J. Nevalainen & H. J. Aho

Authors
  1. T. J. Nevalainen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. J. Aho
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of General Surgery, University of Ulm, Steinhövelstr. 9, D-7900, Ulm, Germany

    Hans G. Beger MD, FACS (Professor of Surgery) & Markus Büchler MD (Professor of Surgery) & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Nevalainen, T.J., Aho, H.J. (1987). Phospholipase A2 in Acute Pancreatitis. In: Beger, H.G., Büchler, M. (eds) Acute Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83027-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83027-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83029-7

  • Online ISBN: 978-3-642-83027-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation