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Renal Effects of Mechanical Ventilation

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Cardiopulmonary Interactions in Acute Respiratory Failure

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 2))

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Abstract

Since the introduction of continuous positive airway pressure (CPAP), and controlled mechanical ventilation (CMV) with positive end-expiratory pressure (PEEP), considerable efforts were made to investigate the side effects of positive airway pressure on cardiocirculatory function. Numerous studies have revealed a partial cardiocirculatory stabilization by blood volume expansion [1] and/or catecholamines [2, 3] as well as by the use of intermittent mandatory ventilation (IMV) or continuous positive airway pressure (CPAP) [4, 5]. However, the negative effects of positive airway pressure on excretory renal function have been of little interest to investigators, even though the first report was already published in 1947 by Drury et al. [6], who observed a decrease in urine flow and urea clearance in healthy volunteers breathing against a CPAP of 40 mmHg. They concluded that “kidney function may be used as a measure of circulatory stress induced by a reduction of effective blood volume” and suggested breathing against positive pressure as a test of circulatory fitness.

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Authors
  1. H. H. Steinhoff
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  2. J. Bergmann
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  3. K. J. Falke
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean Louis Vincent (Assistant-Director) (Assistant-Director)

  2. Department of Surgical Intensive Care, University Hospital of Geneva, CH-1211, Geneva 4, Switzerland

    Peter M. Suter (Director) (Director)

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© 1987 Springer-Verlag Berlin Heidelberg

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Steinhoff, H.H., Bergmann, J., Falke, K.J. (1987). Renal Effects of Mechanical Ventilation. In: Vincent, J.L., Suter, P.M. (eds) Cardiopulmonary Interactions in Acute Respiratory Failure. Update in Intensive Care and Emergency Medicine, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83010-5_13

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  • DOI: https://doi.org/10.1007/978-3-642-83010-5_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17474-5

  • Online ISBN: 978-3-642-83010-5

  • eBook Packages: Springer Book Archive

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