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Hyperthermia and Drugs

  • Chapter
Hyperthermia and the Therapy of Malignant Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 104))

Abstract

Hyperthermia has the potential to modify the cytotoxicity of anticancer drugs and to convert some other drugs to cytotoxic agents having no considerable cytotoxicity at normal temperature. This has been demonstrated by in vitro and in vivo experiments, which are compiled in the first part of this review. The pattern of modification of the dose response curves of the drugs and the degree of change of their effectiveness by heat depends on a great variety of factors; not all these are known at present. In this review an attempt is made to compile as many data as possible on these modifying factors. They will be discussed in the context of each specific drug in order to avoid misleading generalizations, but rather to give a “hyperthermic portrayal” of these drugs.

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Authors and Affiliations

  1. Medizinische Universitätsklinik, Hugstetter Strasse 55, 7800, Freiburg, Germany

    R. Engelhardt

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  1. R. Engelhardt
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  1. Institut für Medizinsche Strahlenbiologie, Universitätsklinikum Essen, Hufelandstrasse 55, 4300, Essen 1, Germany

    Christian Streffer

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© 1987 Springer-Verlag Berlin · Heidelberg

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Engelhardt, R. (1987). Hyperthermia and Drugs. In: Streffer, C. (eds) Hyperthermia and the Therapy of Malignant Tumors. Recent Results in Cancer Research, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82955-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-82955-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82957-4

  • Online ISBN: 978-3-642-82955-0

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