Hyperthermia and Drugs

  • R. Engelhardt
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 104)

Abstract

Hyperthermia has the potential to modify the cytotoxicity of anticancer drugs and to convert some other drugs to cytotoxic agents having no considerable cytotoxicity at normal temperature. This has been demonstrated by in vitro and in vivo experiments, which are compiled in the first part of this review. The pattern of modification of the dose response curves of the drugs and the degree of change of their effectiveness by heat depends on a great variety of factors; not all these are known at present. In this review an attempt is made to compile as many data as possible on these modifying factors. They will be discussed in the context of each specific drug in order to avoid misleading generalizations, but rather to give a “hyperthermic portrayal” of these drugs.

Keywords

Doxorubicin Cyclophosphamide Osteosarcoma Haas Mitomycin 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1987

Authors and Affiliations

  • R. Engelhardt
    • 1
  1. 1.Medizinische UniversitätsklinikFreiburgGermany

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