Skip to main content

Aspects of Infections in Children with Cancer

  • Conference paper
Supportive Care in Cancer Patients

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 108))

Abstract

There is no doubt that the last decade has witnessed an incredible improvement in the treatment of neoplastic diseases. This is true of not only primary treatment of tumors but also supportive care of patients. In this setting, however, infections remain a major problem because of their significant morbidity and mortality, as well as the impediment they frequently pose to the accomplishment of the antineoplastic therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. EORTC-International Antimicrobial Therapy Cooperative Group (1986) Empiric therapy in febrile neutropenic patients: different responses in children and adults (abstract). 26th Interscience conference on antimicrobial agents and chemotherapy, New Orleans, September 28–October 1, 681

    Google Scholar 

  2. Cooper RG, Sumner C (1970) Hospital infection data from a children’s hospital. Med J Aust 2: 1110–1113

    PubMed  CAS  Google Scholar 

  3. Bodey GP, Buckley M, Sathe JS, Freireich EJ (1966) Quantitative relationships between circulating leucocytes and infection in patients with acute leukemia. Ann Intern Med 64: 328–340

    PubMed  CAS  Google Scholar 

  4. Ziegler EF, McCutchan JA, Fierer JA (1982) Treatment of Gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N Engl J Med 307: 1225–1230

    Article  PubMed  CAS  Google Scholar 

  5. Peter G, Pizzo PA, Robichaud KJ, Visconts ER, Farman EN, Zinna SH (1979) Possible protective effect of circulatory antibodies to the shared care glycolipid of Enterobacteriaceae in children with malignancy (abstract). Soc Pediat Res 13: 466

    Google Scholar 

  6. Schimpff SC, Young VM, Greene WH, Vermeulen GD, Moody MK, Wiernik PN (1972) Origin of infection in acute non-lymphocytic leukemia: significance of hospital acquisition of potential pathogens. Ann Intern Med 77: 704–714

    Google Scholar 

  7. Schimpff SC, Greene WH, Young VM et al. (1974) Significance of Pseudomonas aeruginosa in the patient with leukemia or lymphoma. J Infect Dis 130: 24–31

    Article  Google Scholar 

  8. Kurrle E, Bhaduri S, Krieger D et al. (1981) Risk factors for infections of the oropharynx and the respiratory tract in patients with acute leukemia. J Infect Dis 144: 128–136

    Article  PubMed  CAS  Google Scholar 

  9. Kingston JE, Fowler PC, Jackson DB, Potter V, Malpas JS (1985) Experience with central intravenous catheter in a pediatric oncology unit. Eur Pediatr Hematol Oncol 2: 29–34

    Article  Google Scholar 

  10. Pizzo PA (1981) Infectious complications in the child with cancer. I. Pathophysiology of the compromised host and the initial evaluation and management of the febrile cancer patient. J Pediatr 98: 341–354

    Article  PubMed  CAS  Google Scholar 

  11. EORTC International Antimicrobial Therapy Project Group (1978) Three antibiotic regimens in the treatment of infections in febrile granulocytopenic patients with cancer. J Infect Dis 137: 14–29

    Article  Google Scholar 

  12. Pizzo PA, Commers J, Cotton D, Gress J, Hathorn J, Hiemenz J, Longo D, Marshall D, Robichaud KD (1984) Approaching the controversies in antibacterial management of cancer patients. Am J Med 76: 436–449

    Article  PubMed  CAS  Google Scholar 

  13. Abraham JL, Mullen JL (1982) A prospective study of prolonged central venous access in leukemia. JAMA 248: 2868–2873

    Article  Google Scholar 

  14. Prince A, Heller B, Levy J, Heird W (1986) Management of fever in patients with central vein catheters. Pediatr Infect Dis 5: 20–24

    Article  PubMed  CAS  Google Scholar 

  15. Hiemenz J, Skelton J, Pizzo P (1986) Perspective on the management of catheter-related infections in cancer patients. Pediatr Infect Dis 5: 6–11

    Article  PubMed  CAS  Google Scholar 

  16. Pizzo P, Ladisch S, Simon RM, Gill F, Levine AS (1978) Increasing incidence of Gram-positive sepsis in cancer patients. Med Pediatr Oncol 5: 241–244

    Article  PubMed  CAS  Google Scholar 

  17. Viscoli C, Perlino GF, De Bernardi B, Fabbri A, Massimo L, Terragna A (1985) Infections in children with cancer. Ital J Pediatr 11: 37–43

    Google Scholar 

  18. Viscoli C, Perlin GF, Moroni C, Ferrea G, Fabbri A, Haupt R, Massimo L, Terragna A (1984) Gram-positive infections in pediatric cancer patients (abstract). 3rd International symposium on infections in the immunocompromised host, Toronto, June 24–28: 136

    Google Scholar 

  19. Wade JC, Schimpff SC, Newman KA, Wiernik PH (1982) Staphylococcus epidermidis: an increasing cause of infection in patients with granulocytopenia. Ann Intern Med 97: 503–508

    PubMed  CAS  Google Scholar 

  20. EORTC International Antimicrobial Therapy Project Group (1983) Combination of amikacin and carbenicillin with or without cefazolin as empirical treatment of febrile neutropenic patients. J Clin Oncol 1: 597–603

    Google Scholar 

  21. EORTC International Antimicrobial Therapy Project Group (1986) Prospective randomized comparison of three antibiotic regimens for empirical bacteremic infections in febrile granulocytopenic patients. Antimicrob Agents Chemother 29: 263–270

    Google Scholar 

  22. Klastersky J (1986) Concept of empiric therapy with antibiotic combinations: indications and limits. Am J Med 80 [suppl 5 c]: 2–12

    PubMed  CAS  Google Scholar 

  23. EORTC International Antimicrobial Therapy Cooperative Group (1986) Gram-positive septicemias in cancer patients (abstract). 26th Interscience conference on antimicrobial agents and chemotherapy, New Orleans, September 28–October 1: 679

    Google Scholar 

  24. Kosmidis HV, Lusher JM, Shope TC, Ravindranath Y, Dajani AS (1980) Infections in leukemic children: a prospective analysis. J Pediatr 96: 814–819

    Article  PubMed  CAS  Google Scholar 

  25. Nachman JB, Honig GR (1980) Fever and neutropenia in children with neoplastic disease. An analysis of 158 episodes. Cancer 45: 407–412

    Article  PubMed  CAS  Google Scholar 

  26. Pizzo PA, Robichaud KJ, Wesley R, Commers JR (1982) Fever in the pediatric and young adult patient with cancer. A prospective study of 1001 episodes. Medicine 61: 153–165

    Article  PubMed  CAS  Google Scholar 

  27. Viscoli C, Moroni C, Garaventa A, Dini G, Mori P, Ferrea G, Massimo L, Terragna A (1986) Ceftazidime amikacin versus ceftazidime + vancomycin as initial empiric treatment of febrile episodes in neutropenic children (abstract). 4th International symposium on infections in the immunocompromised Host, Ronneby Brunn ( Sweden ), June 15–19: 120

    Google Scholar 

  28. Sorrell TC, Packman DR, Shanker S, Foldes M, Munzo R (1982) Vancomycin therapy for methicillin resistant Staphylococcus aureus. Ann Intern Med 97: 344–350

    PubMed  CAS  Google Scholar 

  29. Jadeja L, Bolivar R, Fainstein V, Keating M, McCredie K, Hay M, Bodey G (1984) Piperacillin plus vancomycin in the therapy of febrile episodes in cancer patients. Antimicrob Agents Chemother 26: 295–299

    PubMed  CAS  Google Scholar 

  30. Karp J, Dick J, Angelopulos C, Charache P, Greene L, Burke P, Saral R (1986) Empiric use of vancomycin during prolonged treatment induced granulocytopenia. Randomized, double blind, placebo-controlled clinical trial in patients with acute leukemia. Am J Med 81: 237–242

    Article  PubMed  CAS  Google Scholar 

  31. Morgan G, Duerden BI, Lilleyman JS (1983) Ceftazidime as a single agent in the management of children with fever and neutropenia. J Antimicrob Chemother 12 [suppl A]: 347–351

    Article  PubMed  Google Scholar 

  32. Fainstein V, Bodey G, Elting L et al. (1983) A randomized study of ceftazidime corn-pared to ceftazidime and tobramycin for the treatment of infections in cancer patients. J Antimicrob Chemother 12 [suppl A]: 101–110

    Article  PubMed  Google Scholar 

  33. Donnelly JP, Marcus RE, Goldman JM, Cohen J, Worsley AM, Catovsky D, Darrel JH, Want SV, Jalton JAD (1985) Ceftazidime as first line therapy for fever in acute leukemia. J Infect 11: 205–215

    Article  PubMed  CAS  Google Scholar 

  34. Pizzo PA, Hathorn JW, Hiemenz J, Browne M, Commers J, Cotton D, Gress J, Longo D, Marshall D, McKnight J, Rubin M, Skelton J, Thaler M, Wesley R (1986) A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N Engl J Med 315: 552–558

    Article  PubMed  CAS  Google Scholar 

  35. EORTC International Antimicrobial Therapy Cooperative Group (1986) Amikacin short or full course plus ceftazidime versus amikacin plus azlocillin for Gram-negative rod bacteremia in granulocytopenic cancer patients (abstract). 26th Interscience conference on antimicrobial agents and chemotherapy, New Orleans, September 28–October 1: 247

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin·Heidelberg

About this paper

Cite this paper

Viscoli, C. (1988). Aspects of Infections in Children with Cancer. In: Senn, HJ., Glaus, A., Schmid, L. (eds) Supportive Care in Cancer Patients. Recent Results in Cancer Research, vol 108. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82932-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-82932-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82934-5

  • Online ISBN: 978-3-642-82932-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics