Skip to main content

Pathology of Lung Cancer

  • Chapter
Lung Tumors

Part of the book series: UICC Current Treatment of Cancer ((1360))

Abstract

Cancer of the lung arises by neoplastic transformation of the normal lining epithelium. Tumors probably begin as a single malignant clone but rapid division and mutation result in different subpopulations and this is reflected in a wide variety of histological patterns, often suggesting differentiation in more than one direction. Nevertheless the majority of lung carcinomas are readily classified into four main types:

  • Squamous cell (epidermoid) 50%

  • carcinoma

  • Adenocarcinoma 20%

  • Large cell carcinoma 10%

  • Small cell carcinoma 20%

  • (Carcinoid 1%) The relative frequency of each type of carcinoma varies considerably between different series. Surgical series are particularly misleading because patients are selected according to operability. The incidence given above is taken from the Mayo Clinic Lung Project.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Further Reading

  • Bolen JW, Thorning D (1982) Histogenetic classification of pulmonary carcinomas. Peripheral adenocarcinoma studied by light microscopy, histochemistry and electron microscopy. Pathol Annu 17: 77–100

    PubMed  Google Scholar 

  • Carter D (1978) Pathology of early squamous cell carcinoma of the lung. Pathol Annu 13: 131–147

    PubMed  Google Scholar 

  • Carter D (1983) Small-cell carcinoma of the lung. Am J Surg Pathol 7: 787–795

    Article  PubMed  CAS  Google Scholar 

  • Carter D, Eggleston JC (1980) Tumours of the lower respiratory tract (Atlas of tumour pathology, second series, Fasc. 17). Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  • Edwards CW (1984) Alveolar carcinoma: a review. Thorax 39: 166–174

    Article  PubMed  CAS  Google Scholar 

  • Gould VE, Linnoila RI, Memoli VA, Warren WH (1983) Neuroendocrine cells and neuroendo-crine neoplasms of the lung. Path Annu 18: 287–330

    Google Scholar 

  • Hammond ME, Sanse WT (1985) Large cell neuroendocrine tumours of the lung — clinical significance and histopathologic definition. Cancer 56: 1624–1629

    Article  PubMed  CAS  Google Scholar 

  • Hirsch FR, Osterlind K, Hansen HH (1983) The prognostic significance of histopathologic sub-typing of small cell carcinoma of the lung according to the classification of the World Health Organisation. Cancer 52: 2144–2150

    Article  PubMed  CAS  Google Scholar 

  • Kimula Y (1978) A histochemical and ultrastructural study of adenocarcinoma of the lung. Am J Surg Pathol 2: 253–264

    Article  PubMed  CAS  Google Scholar 

  • Matthews MJ (1985) Pathology of small cell lung cancer. Clin Oncol 4: 11–29

    Google Scholar 

  • Matthews MJ, Mackay B, Lukeman J (1983) The pathology of non-small cell carcinoma of the lung. Semin Oncol 10: 34–55

    PubMed  CAS  Google Scholar 

  • McDowall EM, Becci PJ, Barrett LA, Trump BF (1978) Morphogenesis and classification of lung cancer. In: Harris CC (ed) Pathogenesis and therapy of lung cancer. Lung biology in health and disease, vol 10. Dekkar, New York pp 445–519

    Google Scholar 

  • Saccomanno G, Archer VE, Auerback O, Saunder RP, Brennan LM (1973) Development of carcinoma of the lung as reflected in exfoliated cells. Cancer 33: 256–270

    Article  Google Scholar 

  • Singh G, Katyal SL, Ordonez NG, Dail DH, Negishi Y, Weedn VW, Marcus PB, Weldon-Linne M, Axiotis CA, Alvarez-Fernandez E, Smith WI (1984) Type II pneumocytes in pulmonary tumours. Arch Pathol Lab Med 108: 44–48

    PubMed  CAS  Google Scholar 

  • Spencer H, Dail DH, Arneaud J (1980) Non-invasive bronchial epthelial papillary tumours. Cancer 45: 1486–1497

    Article  PubMed  CAS  Google Scholar 

  • Vollmer RT, Birch R, Ogdon L, Crossman JD (1985) Subclassification of small cell cancer of the lung. The southeastern cancer study group experience. Hum Pathol 16: 247–252

    Article  PubMed  CAS  Google Scholar 

  • Whimster WF (1983) Tumours of the trachea, bronchus, lung and pleura. (Diagnostic tumour bibliographies, no 1) Pitman, London

    Google Scholar 

  • WHO (1981) Histological typing of lung tumours (International histological classification of tumours No 1) 2nd edn, World Health Organisation, Geneva

    Google Scholar 

  • Wilson TS, McDowell EM, Marangos PJ, Trump BF (1985) Histochemical studies of dense-core granulated tumours of the lung. Arch Pathol Lab Med 109: 613–620

    PubMed  CAS  Google Scholar 

  • Woolner EM, Fontana RS, Sanderson DR, Miller WE, Muhm JR, Taylor WF, Uhlenhopp MA (1981) Mayo lung project: evaluation of lung cancer screening through December 1979. Mayo Clin Proc 50: 544–555

    Google Scholar 

  • Yesner R (1985) Classification of lung cancer histology. New Engl J Med 312: 652–653

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Addis, B.J. (1988). Pathology of Lung Cancer. In: Hoogstraten, B., Addis, B.J., Hansen, H.H., Martini, N., Spiro, S.G. (eds) Lung Tumors. UICC Current Treatment of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82873-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-82873-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16920-8

  • Online ISBN: 978-3-642-82873-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics