Abstract
Vasodilators can be administered in the critically ill primarily to increase cardiac output (by reducing left ventricular afterload) and to releive pulmonary vascular congestion (by increasing venous capacitance). Vasodilators present the advantage to increase myocardial oxygen supply/demand ratio and improve myocardial ischemia. Vasodilators could also favourably influence peripheral distributior of blood flow.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ducas J, Schick U, Girling L, Prewitt RM (1985) Effects of reduced resistive afterload on left ventricular pressure-volume relationship. Am J Physiol 248: H163–H169
Voss GI, Katona PG, Dauchot PJ (1985) Effectiveness of sodium nitroprusside as a function of total peripheral resistance in the anesthetized dog. Anesthesiology 62: 130–134
Fadem SZ, Hernandez-Llamas G, Patak RV, Rosenblatt SG, Lifschitz MD, Stein JH (1982) Studies on the mechanism of sodium excretion during drug-induced vasodilation in the dog. J Clin Invest 69: 604–610
Faxon DP, Creager MA, Halperin JL, Bernard DB, Ryan TJ (1984) Redistribution of regional blood flow following angiotensin converting enzyme inhibitor: Comparison of normal subjects and patients with heart failure. Am J Med May 31: 104–110
Hammerman H, Kloner RA, Alker KJ, Schoen FJ, Braunwald E (1985) Effects of transient increased afterload during experimentally induced acute myocardial infarction in the dog. Am J Cardiol 55: 566–570
Collins P, Sheridan D (1985) Improvement in angina pectoris with alpha-adrenoceptor blockade. Br Heart J 53: 488–492
Sivarajan M, Amory DW, McKenzie SM (1985) Regional blood flows during induced hypotension produced by nitroprusside or trimethaphan in the rhesus monkey. Anesth Analg 64: 759–766
Feldman RL, Conti CR, Pepine CJ (1983) Comparison of coronary hemodynamic effects of nitroprusside and sublingual nitroglycerin with anterior descending coronary arterial occlusion. Am J Cardiol 52: 915–920
Arnold WP, Longnecker DE, Epstein RM (1984) Photodegradation of sodium nitroprusside: Biologic activity and cyanide release. Anesthesiology 61: 254–260
Packer M, Meller J, Medina N, Gorlin R, Herman MV (1979) Rebound hemodynamic events after abrupt withdrawal of nitroprusside in patients with severe chronic heart failure. N Engl J Med 301: 1193–1197
Packer M, Meller J, Medina N, Yushak M (1983) Quantitative differences in the hemodynamic effects of captopril and nitroprusside in severe chronic heart failure. Am J Cardiol 51: 183–188
Dzau VJ, Hollenberg NK (1984) Renal response to captopril in severe heart failure: Role of furosemide in natriuresis and reversal of hyponatremia. Ann Intern Med 100: 777–782
Abrams J (1985) Pharmacology of nitroglycerin and long-acting nitrates. Am J Cardiol 56: 12A–18A
Col J, Col-Debeys C, Lavenne-Pardonge E, Meert P, Hericks L, Broze MC, Moriau M (1985) Propylene glycol-induced heparin resistance during nitroglycerin infusion. Am Heart J 110: 171–173
Amstrong PW, Amstrong JA, Marks LS (1980) Pharmacokinetic hemodynamic studies of nitroglycerin ointment in congestive heart failure. Am J Cardiol 46: 670–676
Majid PA, Sharma B, Taylor SH (1971) Phentolamine for vasodilator treatment of severe heart failure. Lancet 2: 719–723
Maekana K, Liang CS, Tsui A, Chen BT, Kawashima S (1984) Vasodilative effect of hydralazine in awake dogs: The roles of prostaglandins and the sympathetic nervous system. Circulation 70: 908–916
Swartz MT, Kaiser GC, Willman VL, Codd JE, Tyras DH, Barner HB (1981) Continuous hydralazine infusion for afterload reduction. Ann Thor Surg 32: 188–192
Vincent JL, Sarot J, Unger P, Kahn RJ. Afterload reduction in the critically ill: Nicergoline versus sodium nitroprusside (submitted)
Bolli R, Brandon TA, Fischer DJ, Fernandez GC, Miller RR (1983) Beneficial effects of the alpha-adrenergic antagonist nicergoline during acute myocardial ischemia and reperfusion in the dog. Am Heart J 106: 1014–1023
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Vincent, J.L. (1986). Vasodilating Therapy. In: Vincent, J.L. (eds) 6th International Symposium on Intensive Care and Emergency Medicine. Update in Intensive Care and Emergency Medicine, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82801-0_80
Download citation
DOI: https://doi.org/10.1007/978-3-642-82801-0_80
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16508-8
Online ISBN: 978-3-642-82801-0
eBook Packages: Springer Book Archive