Persistent Pulmonary Hypertension in the Newborn

  • H. Stopfkuchen
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 1)


By seven weeks of gestational age, the mature pattern of the pulmonary circulation linking the heart and lungs is established. The arteries derived from the pulmonary circulation develop concurrently with the conducting airways and by 16 weeks in utero, all pre-acinar arterial branches are formed. These arteries grow further by increasing their length and diameters but new pre-acinar arteries do not appear after this time. Intra-acinar blood vessels develop postnatally. Throughout gestation intrapulmonary arterial wall thickness (medial muscular layers) is 14–20% of the external arterial diameter.


Pulmonary Hypertension Pulmonary Vascular Resistance Pulmonary Blood Flow Hypoxic Pulmonary Vasoconstriction Newborn Lamb 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

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  • H. Stopfkuchen

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