Abstract
Blood is ordinarily the best substitute for blood. However, there exists a variety of circumstances in which the use of blood may be impractical, or in which blood’s rheologic or immunologic properties are suboptimal. A number of examples may readily be cited: Trauma or other hemorrhage occurring at a location distant from transfusion facilities; Presence of a rare blood type, making it difficult to locate suitable blood; Presence of immune hemolysis or isoimmunization, making proper cross-matching difficult; Ex-vivo organ preservation; Underperfused, radio-and-chemoresistant tumors; Refusal of transfusion on religious grounds. Each of these circumstances could be a context in which an oxygen-carrying blood substitute could be of use, especially if it had a long shelf life under simple storage conditions and was a true solution or an emulsion with a particle size smaller than that of erythrocytes.
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© 1986 Springer-Verlag Berlin Heidelberg
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Hammerschmidt, D.E., Vercellotti, G.M. (1986). Perfluorocarbons as Blood Substitutes: Limitation of Complement Activation in the Control of Adverse Reactions. In: Vincent, J.L. (eds) 6th International Symposium on Intensive Care and Emergency Medicine. Update in Intensive Care and Emergency Medicine, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82801-0_52
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DOI: https://doi.org/10.1007/978-3-642-82801-0_52
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