Changes in Systemic Microvascular Permeability in Sepsis and Septic Shock

  • L. G. Thijs
  • A. B. J. Groeneveld
  • A. A. van Lambalgen
  • G. C. van den Bos
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 1)


Generalized soft tissue edema both in dependent and nondependent parts of the body is a remarkable feature of severe sepsis and septic shock. Usually, septic patients need substantial intravascular volume replacement, much greater than could be anticipated on the basis of measurable fluid losses [3]. Fluid balances are strongly positive in many cases to become negative when the patient recovers, a tendency which is often not observed in nonsurvivors [15]. Marked persistent peripheral edema may therefore be an ominous prognostic sign. Tissue edema may have a number of serious clinical sequelae like generalized organ dysfunction, interference with oxygen diffusion from the intravascular compartment to the cell (longer diffusion distances) and abnormalities in drug metabolism due to changes in the volume of distribution [3]. Several mechanisms can be involved in the formation of edema in septic patients. Microvascular fluid exchange is governed by the Starling forces [11, 13].


Septic Shock Septic Patient Colloid Osmotic Pressure Transcapillary Escape Rate Starling Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • L. G. Thijs
  • A. B. J. Groeneveld
  • A. A. van Lambalgen
  • G. C. van den Bos

There are no affiliations available

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