Glucagon — An Important Therapeutic Agent
Endocrinology is finding an increasing role and importance in Critical Care and Emergency Medicine. Hormones clearly mediate much of the body’s homeostatic response to critical illness . For example, catecholamines, aldosterone and anti-diuretic hormone are each released into the circulation during states of hypotension and shock. Endocrine and metabolic problems are common in critically ill patients. More than two-thirds of critically ill patients manifest abnormalities (at least biochemically) in either thyroid function , calcium metabolism [2, 21], or magnesium metabolism . Hormones are also important therapeutic agents. Many hormones, peptides and receptor antagonists have been considered in the treatment of shock . The purpose of this paper is to review the pharmacology and physiology of the hormone glucagon — as it applies to critical and emergency care.
KeywordsCardiogenic Shock Alcoholic Hepatitis Cardiovascular Action Endotoxin Shock Glucagon Concentration
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- 3.Chernow B, Reed C, MeyerhoffJ, Lake CR, Geelhoed G, Beardsley D, Holaday JW (1984) Verapamil antagonizes glucagon’s chronotropic effect. Circ Shock 13: 96–97Google Scholar
- 4.Chernow B, Clapper M, Malcolm D, Holaday JW (1976) Glucagon has a chronotropic effect on rats. Clin Res 32: 687AGoogle Scholar
- 6.Chernow B, Roth BL (1986) Pharmacologic support of the cardio-vasculature in septic shock. In: Sibbald WJ, Sprung CL (eds) Perspectives on Sepsis and Septic Shock, Society of Critical Care Medicine, Fullerton, pp 173–202Google Scholar
- 7.Deraney MF (1971) Glucagon? One answer to cardiogenic shock. Amer J Med Sci 261: 149154Google Scholar
- 8.Farah AE (1983) Glucagon and the circulation. Pharmacol Reviews 35: 181–217Google Scholar
- 15.Parmley WW, Glick G, Sonnenblick EH 61968) Cardiovascular effects of glucagon in man. N Engl J Med 279: 12–17Google Scholar
- 17.Teich S, Malcolm D, Holaday JW, Chernow B (1985) Beneficial effects of glucagon in endotoxin shock in rats. Circ Shock 16: 95Google Scholar