Measurement of Mixed Venous O2 Saturation in the Perioperative Period

  • K. Reinhart
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 1)


Does mixed venous oxygen saturation (\(S\bar v{O_2}\)O2) yield better information on the cardiorespiratory situation of the patient than the parameters usually measured: heart rate, systemic arterial pressure, cardiac filling pressures and cardiac output? From a theoretical point of view it should, and this was already pointed out more than 100 years ago in 1872 by the German physiologist Pflüger, who was the first to realize that the task of the cardiorespiratory sytem is to provide the organism with oxygen and substrates and to remove the waste products [11]. He stated that it is the oxygen needs of tissue cells that govern and regulate the whole system and that “arterial oxygen content, arterial pressures, velocity of blood stream, mode of cardiac work and mode of respiration all are incidental and subordinate, they all combine their actions in service to the cells.”


Cardiac Output Hemodynamic Parameter Oxygen Extraction Mixed Venous Oxygen Saturation Cardiac Filling Pressure 
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  1. 1.
    Beale PL, McMichan JC, Marsh MB, Sill JC, Souther PA (1982) Continuous monitoring of mixed venous saturation in critically ill patients. Anesth Analg 61: 513Google Scholar
  2. 2.
    Cain SM (1977) Arterial lactate response in dogs made apneic of breathing nitrogen. J Appl Physiol 42: 39PubMedGoogle Scholar
  3. 3.
    Cole IS, Martin WE, Cheung PW, Johnson CC (1972) Clinical studies with a solid state fibre optic catheter. Am J Cardiol 29: 383PubMedCrossRefGoogle Scholar
  4. 4.
    Del Guerico LRM, Commaraswamy RP, Feins NR, Wollmann SB, State D (1976) Pulmonary arteriovenous admixture and the hyperdynamic vascular state in surgery for portal hypertension. Surgery 56: 57Google Scholar
  5. 5.
    Dexter L, Whittenberger FW, Haynes WT, Goodale R, Sawyer CG (1951) Effect of excercise on circulatory dynamics of normal individuals. J Appl Physiol 3: 439PubMedGoogle Scholar
  6. 6.
    Fick A (1870) Über die Messung des Blutquantum in den Herzventrikeln. Sitzungsbericht Phys Med Ges Würzburg. Bd II: X VIGoogle Scholar
  7. 7.
    Finely RJ, Duff JH, Holliday RL, Jones D, Marchuk JB (1975) Capillary muscle blood flow in human sepsis. Surgery 78: 87Google Scholar
  8. 8.
    Hickham JB, Cargill WH (1947) Effect of exercise on cardiac output and pulmonary arterial pressure in normal persons and in patients with cardiovascular disease and pulmonary emphysema. J Clin Invest 27: 10CrossRefGoogle Scholar
  9. 9.
    Kawakami Y, Kishi F, Yamamato H, Miyamoto K (1983) Relation of oxygen delivery mixed venous oxygenation and pulmonary hemodynamics to prognosis in chronic obstructive pulmonary disease. N Engl J Med 308: 1045PubMedCrossRefGoogle Scholar
  10. 10.
    Moss GS, Erve PP, Schumer W (1969) Effect of endotoxin on mitochondrial respiration. Surg Forum 20: 24PubMedGoogle Scholar
  11. 11.
    Pflüger E (1872) Über die Diffusion des Sauerstoffs, den Ort und die Gesetze der Oxydationsprozesse im thierischen Organismus. Pflügers Arch Gesamte Physiol Menschen und der Thiere 6: 43CrossRefGoogle Scholar
  12. 12.
    Reinhart K (1984) Zur Auswirkung der Sympathikusblockade bei der Kombination von thorakaler Periduralanalgesie und Allgemeinanästhesie auf die perioperative Hämodynamik und den Sauerstoffverbrauch bei Risikopatienten. Habilitationsschrift, FReie Universität Berlin FB2Google Scholar
  13. 13.
    Shoemaker WC, Czer LSC (1979) Evaluation of the biologic importance of various hemodynamic and oxygen transport variables. Crit Care Med 7: 237PubMedCrossRefGoogle Scholar
  14. 14.
    Stanley TH, Amaral JI (1974) Periodic analysis of mixied venous oxygen tension to monitor the adequacy of perfusion during and after cardipulmonary bypass. Canad Anesth Soc J 21: 454CrossRefGoogle Scholar
  15. 15.
    Stanley TH, Voider I, Kolff WI (1973) Extrinsic artifical heart control via mixed venous blood gas analysis. Amer Soc Artif Int Organs 19: 258CrossRefGoogle Scholar
  16. 16.
    Tinker JH, Michenfelder JD (1978) Cardiac cyanide toxicity induced by nitroprusside in the dog: potential for reversal. Anesthesiology 49: 109PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1986

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  • K. Reinhart

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