Abstract
In order to fulfill its primary function as a gas exchanger the lung has a very large contact surface between air and blood. While this is an advantage for gas exchange it also provides a very large target for numerous mediators of lung injury. The barrier set up between air and blood is made up of alveolar epithelium and capillary endothelium which enclose the connective tissue fibres of the interstitial space. Although this barrier is freely permeable to water there is an important mechanism which prevents exudation of liquid into the alveolar space. This is based on two factors
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a low permeability of the barrier to hydrophilic solutes and
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active transport of solute, including albumin, across the barrier into the blood.
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References
Basran GS, Byrne AJ, Hardy JG (1985) A non-invasive technique for monitoring lung vascular permeability in man. Nuclear Medicine Communications 6: 3–10
Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keogh BA (1984) Interstitial lung diseases of unknown cause. N Engl J Med 310: 154–165
Dauber IM, Pluss WT, Van Grondelle A, Trow RS, Weil JV (1985) Specificity and sensitivity of noninvasive measurement of pulmonary vascular protein leak. J Appl Physiol 59: 564574
Duchateau J, Haas M, Schreyen H, Radoux L, Sprangers I, Noel FX, Braun M, Lamy M. (1984) Complement activation in patients at risk of developing the adult respiratory distress syndrome. Am Rev Respir Dis 130: 1058–1064
Dueck R (1984) Gas exchange. In: Jones JG (ed) Effects of anesthesia and surgery on pulmonary mechanisms and gas exchange. Int Anes Clinics. Little Brown and CO, Boston, vol 22 p 14
Feeley T, Minty BD, Scudder C, Jones JG, Teng N (1985) Effect of human monoclonal IgM antibodies on endotoxin-induced lung injury in the rat. Brit J Anaesth 57: 826 P
Fein A, Grossman RF, Jones JG, Goodman PC, Murray JF (1979) Evaluation of transthoracic electrical impedence in the diagnosis of pulmonary edema. Circulation 60: 11561160
Greene R, Boggis CRM, Jantsch HS, Tomashefski JF (1985) Radiography and angiography of the pulmonary circulation In: Zapol WM, Falke KJ Acute Respiratory failure, Marcel Dekker, New York, Basel vol 24: 275–302
Henderson RF (1984) Use of bronchoalveolar lavage to detect lung damage. Environmental Health Perspectives 56: 115–129
Jefferies AL, Coates G, O’Brodovich H (1984) Pulmonary epithelial permeability in hyaline-membrane disease. N Engl J Med 311: 1075–1080
Jones JG, Grossman RF, Berry M, Slavin G, Hulands GH, Minty B (1979) Alveolar-capillary membrane permeability. Correlation with functional, radiographic and post mortem changes after fluid aspiration. Am Rev Respir Dis 120: 399–410
Jones JG, Minty BD, Lawler P, Hulands G, Grawley JCW, Veall N (1980) Increased alveolar epithelial permeability in cigarette smokers. Lancet 1: 66–68
Jones JG (1984) Mechanisms and measurement of injury to the alveolar-capillary barrier. ed Jones JG, Effects of anesthesia and surgery on pulmonary mechanisms and gas exchange. Int Anesth Clin, Little, Brown and Co, Boston. 22: 31–148
Lemen R, Jones JG, Graf PD, Cowan G. (1975) Closing volume changes in alloxan-induced pulmonary edema in anaesthetized dogs. J Appl Physiol 39: 235–241
Minty BD, Scudder C, Grantham C, Jones JG, Bakhle YS, (1985) Changes in pulmonary permeability and metabolic funtion following ANTU lung injury. Amer Rev Respir Dis 131: A340
Morel D, Dargent F, Bachmann M, Suter P, Junod AF. (1985) Pulmonary extraction of serotonin and propranolol in patients with adult respiratory distress syndrome. Am Rev Respir Dis 132: 479–484
Weibel ER (1984) The pathway for oxygen. Harvard University Press, Cambridge, Mass and London p 231–271
Weinberg PF, Matthay MA, Webster RO, Roskos KV, Goldstein IM, and Murray JF. (1984) Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Respir Dis 130: 791–796
Whitcomb ME, Dixon GF (1984) Gallium scanning, bronchoalveolar lavage, and the national debt. Chest 85: 719–721
White DA, Gellene RA, Gupta S, Cunningham-Rundles C, Stover DE (1985) Pulmonary cell populations in the immunosuppressed patient. Chest 88: 352–359
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© 1986 Springer-Verlag Berlin Heidelberg
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Jones, J.G. (1986). Evaluation of Acute Lung Injury. In: Vincent, J.L. (eds) 6th International Symposium on Intensive Care and Emergency Medicine. Update in Intensive Care and Emergency Medicine, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82801-0_3
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DOI: https://doi.org/10.1007/978-3-642-82801-0_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-16508-8
Online ISBN: 978-3-642-82801-0
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