Fibrin-Specific Thrombolysis with Tissue-Type Plasminogen Activator and Single Chain Urokinase-Type Plasminogen Activator
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Mammalian blood contains an enzymatic system capable of dissolving blood clots, which is called the fibrinolytic enzyme system. The fibrinolytic system comprises a proenzyme, plasminogen, which can be converted to the active enzyme plasmin, which will degrade fibrin. Plasminogen activation is mediated by plasminogen activators which are classified as either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Inhibition of the fibrinolytic system may occur at the level of the activators or at the level of generated plasmin .
KeywordsPlasminogen Activator Fibrin Clot Fibrinolytic System Plasminogen Activation Catalytic Rate Constant
- 1.Cohen D (1980) On the regulation and control of fibrinolysis. Edward Kowalski Memorial Lecture. Thromb Haemost 43: 77–89Google Scholar
- 3.Cohen D (1986) Tissue-type plasminogen activator (t-PA) and single chain urokinase-type plasminogen activator (scu-PA). Potential for fibrin-specific thrombolytic therapy. Progress in Haemostasis 8:(in press)Google Scholar