Fibrin-Specific Thrombolysis with Tissue-Type Plasminogen Activator and Single Chain Urokinase-Type Plasminogen Activator
Mammalian blood contains an enzymatic system capable of dissolving blood clots, which is called the fibrinolytic enzyme system. The fibrinolytic system comprises a proenzyme, plasminogen, which can be converted to the active enzyme plasmin, which will degrade fibrin. Plasminogen activation is mediated by plasminogen activators which are classified as either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Inhibition of the fibrinolytic system may occur at the level of the activators or at the level of generated plasmin .
KeywordsPlasminogen Activator Fibrin Clot Fibrinolytic System Plasminogen Activation Catalytic Rate Constant
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