Infarct Size Limitation: Principles and Problems

  • D. J. Hearse
  • D. M. Yellon
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 1)


During the last 15 years the concept of therapeutic infarct size limitation has become well established, with many experimental and clinical studies producing encouraging results [18–20, 26]. However, during the last two to three years there have been an increasing number of experimental reports [4, 12, 14, 21, 27] have begun questioning whether traditional “anti-infarct” agents such as beta blockers [24, 25] are really able to limit myocardial infarct size [10]. In a major review of the effects of drugs upon evolving myocardial infarction, Opie in 1980 [23] cautiously concluded that the “time has not yet come so introduce anti-infarct agents into general cardiological practice”.


Infarct Size Coronary Occlusion Border Zone Infarct Size Reduction Myocardial Infarct Size 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • D. J. Hearse
  • D. M. Yellon

There are no affiliations available

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