Solvent Selection and Modification for FAB Mass Spectrometry

  • K. L. Busch
  • K. J. Kroha
  • R. A. Flurer
  • G. C. DiDonato
Part of the Springer Series in Chemical Physics book series (CHEMICAL, volume 44)

Abstract

Fast atom bombardment (FAB) mass spectrometry involves the dissolution of the sample in a liquid matrix, and the bombardment of the sample surface with energetic primary particles. A small fraction of the sample is sputtered as secondary ions, and another fraction is damaged by the irradiation. Since FAB experiments persist for extended periods, during the analysis the sample will have ample time to react with the matrix itself, with matrix impurities, and with reactive species formed during irradiation. A liquid matrix can actually trap and concentrate these reactive intermediates, making the resultant spectral complication almost inevitable.

Keywords

Surfactant Glycerol Dopamine Lysine Ketone 

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References

  1. 1.
    K.L. Busch, S.E. Unger, A. Vincze, R.G. Cooks, and T. Keough, J. Am. Chem. Soc., 104, 1507 (1982).CrossRefGoogle Scholar
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    K.L. Buscri and K.J. Kroha: 33rd Annual Conference on Mass Spectrometry and Allied Topics, San Diego, CA, May 1985.Google Scholar
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    G.C. DiDonato and K.L. Busch: Anal. Chim. Acta, 171, 233 (1985).CrossRefGoogle Scholar
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    K.L. Busch, G.C. DiDonato, K.J. Kroha, and L.R. Thtle, 1985 Pittsburgh Conference, February 1985, page 371.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. L. Busch
    • 1
  • K. J. Kroha
    • 1
  • R. A. Flurer
    • 1
  • G. C. DiDonato
    • 1
  1. 1.Department of ChemistryIndiana UniversityBloomingtonUSA

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