Abstract
The sensitivity and specificity of static SIMS can be increased dramatically by using chemical derivatization to produce “preformed” ions. This sensitivity can extend to the parts-per-billion (ppb) range for selected components in complex mixtures such as body fluids. We have applied derivatization/SIMS to several classes of compounds, including peptides [1,2], saccharides [3], ketones and ketosteroids [4] and amine-containing drugs [5].
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M.M. Ross, D.A. Kidwell, R.J. Colton, Int. J. Mass Spectrom. Ion Proc., 63 141 (1985).
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© 1986 Springer-Verlag Berlin Heidelberg
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Ross, M.M., Campana, J.E., Colton, R.J., Kidwell, D.A. (1986). Aspects and Applications of Derivatization/SIMS. In: Benninghoven, A. (eds) Ion Formation from Organic Solids (IFOS III). Springer Proceedings in Physics, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82718-1_11
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DOI: https://doi.org/10.1007/978-3-642-82718-1_11
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