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Preoperative (Neoadjuvant) Chemotherapy pp 41–53Cite as

Implications of Certain Cell Kinetic and Biological Parameters for Preoperative Chemotherapy

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 103))

Abstract

The object of cancer chemotherapy is to do the maximum damage to the tumor and the minimum damage to the patient. This objective is most likely to be achieved when fulldose intensive drug combinations are administered on a frequent intermittent schedule at the earliest opportunity in the course of the disease. Experimental evidence to support this contention has been available for over a decade from laboratory studies and certainly provides a sound basis for preoperative chemotherapy. Those data will be reviewed briefly in this presentation, with emphasis on their demonstrated and potential clinical relevance.

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Author information

Authors and Affiliations

  1. Laboratory of Cellular Chemotherapy, Imperial Cancer Research Fund, Lincoln’s Inn Fields, London, WC2A 3PX, Great Britain

    B. T. Hill

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  1. B. T. Hill
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Editors and Affiliations

  1. Cancer Control Agency of British Columbia, 600 West 10th Avenue, Vancouver, B.C., V5Z 4E6, Canada

    Joseph Ragaz M. D. , Pierre R. Band M. D.  & James H. Goldie M.D. ,  & 

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© 1986 Springer-Verlag Berlin Heidelberg

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Hill, B.T. (1986). Implications of Certain Cell Kinetic and Biological Parameters for Preoperative Chemotherapy. In: Ragaz, J., Band, P.R., Goldie, J.H. (eds) Preoperative (Neoadjuvant) Chemotherapy. Recent Results in Cancer Research, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82671-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-82671-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82673-3

  • Online ISBN: 978-3-642-82671-9

  • eBook Packages: Springer Book Archive

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