Abstract
Preoperative adjuvant chemotherapy in experimental tumors is not new; more than 25 years ago Brock (1959) described the advantage of preoperative chemotherapy in a rat tumor (Table 1). The results were quite impressive, especially if these tumors were more than 10 g at the time of treatment. Not all tumors show a similar response and for that reason it is useful to compare different models. This report describes the response of three mouse tumors to adjuvant chemotherapy with cyclophosphamide given before or after surgical removal of the primary tumor. In order to obtain early metastasis, the tumors were inoculated into the mouse foot pad (Mulder et al. 1983). The basic data on the three tumors are presented in Table 2.
The following also participated in this study: J.H.Mulder, J. de Ruiter, P.Lelieveld, M.B.Edel-stein, T. F. C. Gerritsen, R. J. F. Middeldorp, T. Smink, and L. K. J. Idsenga
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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van Putten, L.M. (1986). Experimental Preoperative Chemotherapy. In: Ragaz, J., Band, P.R., Goldie, J.H. (eds) Preoperative (Neoadjuvant) Chemotherapy. Recent Results in Cancer Research, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82671-9_4
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DOI: https://doi.org/10.1007/978-3-642-82671-9_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82673-3
Online ISBN: 978-3-642-82671-9
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