Preliminary Results of Preoperative Chemotherapy with a Combination of Platinum-Bleomycin Administered in 5-Day Cycles in Carcinoma of the Bronchus

  • J. Clavier
  • L. Israël
  • G. Nouvet
  • Y. Raut
  • J.-J Gres
  • J.-F Morère
  • C. Zabbe
  • G. Lerebours-Pigeonnière
  • J.-L. Breau
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 103)

Abstract

The results obtained with local treatments for inoperable squamous carcinomas of the lung (surgery with or without radiotherapy) depend solely on the stage of the tumor at the time of the operation and have been the same for several decades. We decided to conduct a preliminary, nonrandomized trial of preoperative chemotherapy in these cases because of: (1) the stable and reproducible nature of the postoperative survival curves which enable us to evaluate, if not measure, any possible therapeutic benefit, (2) the effectiveness of 5-day cycles of the combination of platinum-bleomycin in the histological group of squamous carcinomas (Israel et al. 1981a, 1981b; Elson et al. 1982), (3) the possible importance of the DNA repair process in the clinical resistance of these cancers and the role of the above combination in the inhibition of these processes (Okuyama and Mishina 1980; Israel et al. 1985).

Keywords

Toxicity Magnesium Hydration Platinum Creatinine 

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References

  1. Breau JL, Israël L, Pochmalicki G (1983) Efficacité de la méthylprednisolone dans la prévention des vomissements dus aux sels de platine dans un essai randomisé. Bull Cancer 70: 230Google Scholar
  2. Elson DL, Holm ME, Reed RC (1982) Bleomycin infusion plus cisplatin effective induction therapy for squamous cell carcinoma. Proc ASCO 1: 147 (Abstract C-572)Google Scholar
  3. Israël L, Aguilera J, Breau JL (1981 a) Traitement des cancers épidermoides par bléomycine et platine en administration continue prolongée. Série préliminaire de 80 cas avec 75% de réponses objectives. Nouv Presse Méd 10: 1817–1824PubMedGoogle Scholar
  4. Israël L, Aguilera J, Breau JL (1981 b) Preliminary report of 70% response rate in squamous cell ca of the lung with a 6 consecutive days combination of cis-platinum bleomycin. Proc ASCO 1: 508 (Abstract C-685)Google Scholar
  5. Israël L, Breau JL, Morère JF, Lepage E, Aguilera J (1985) Inhibition de la réparation de l’ADN, objectif majeur des chimiothérapies anticancéreuses. A propos de 680 cas de combinaison platinebléomycine en continu. Ann Méd Int 1: 17–20Google Scholar
  6. Okuyama S, Mishina H (1980) Consecutive therapy of cancer aimed at perpetuation of repairable damage: a hypothesis unifying radiotherapy and chemotherapy. J Clin Hematol Oncol 10: 83–93Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. Clavier
    • 1
  • L. Israël
    • 1
  • G. Nouvet
    • 1
  • Y. Raut
    • 1
  • J.-J Gres
    • 1
  • J.-F Morère
    • 1
  • C. Zabbe
    • 1
  • G. Lerebours-Pigeonnière
    • 1
  • J.-L. Breau
    • 1
  1. 1.Service de PneumologieHôpital Augustin MorvanBrestFrance

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