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Eine Analyse Prognostischer Faktoren bei Non-Hodgkin-Lymphomen

  • Conference paper
Prognose- und Entscheidungsfindung in der Medizin

Part of the book series: Medizinische Informatik und Statistik ((MEDINFO,volume 62))

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Summary

An analysis of prognostic factors in Non-Hodgkin’s lymphomas is presented. Regarding overall survival, calculations were based on Cox’s proportional hazard regression model using a stepwise forward procedure for selection of parameters. Serum-LDH activity, performance status and grade of malignancy as histologically defined by the Kielclassification proved to be the most important prognostic factors, age of the patient at the time of diagnosis was of minor importance. For an analysis of the course of disease, a “nonhomogenous Markov illnessdeath process” was assumed. This model allows for the estimation of the force of transition from one state of disease to another. So, it was seen, that the intensity of reaching a complete remission is fairly constant in time, whereas the risk of relapse declines about two years after diagnosis. Furthermore, the proposed model permits to estimate the risk factors for any particular transition in the course of disease. These calculations revealed, that the prognostic importance of histology is mainly related to the risk of death before reaching a complete remission. In contrast, serum-LDH activity is of importance also for the risk of relapse after reaching a complete remission. The proposed model for analysis of the course of disease offers the possibility to a clearer and more disease-related analysis of prognostic variables in diseases with various different states in their course.

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Authors and Affiliations

  1. Abt. Innere Medizin II — Medizinische Klinik, Eberhard-Karls-Universität Tübingen, Otfried-Müller-Straße, D-7400, Tübingen 1, Deutschland

    B. Steinke

  2. Institut für Medizinische Biometrie, Eberhard-Karls-Universität Tübingen, Otfried-Müller-Straße, D-7400, Tübingen 1, Deutschland

    J. Mau

Authors
  1. B. Steinke
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  2. J. Mau
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Statistik und Biomathematik, Universität Düsseldorf, Moorenstr.5, 4000, Düsseldorf 1, Deutschland

    Hans Joachim Jesdinsky  & Hans Joachim Trampisch  & 

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© 1985 Springer-Verlag Berlin Heidelberg

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Steinke, B., Mau, J. (1985). Eine Analyse Prognostischer Faktoren bei Non-Hodgkin-Lymphomen. In: Jesdinsky, H.J., Trampisch, H.J. (eds) Prognose- und Entscheidungsfindung in der Medizin. Medizinische Informatik und Statistik, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82651-1_36

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  • DOI: https://doi.org/10.1007/978-3-642-82651-1_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16068-7

  • Online ISBN: 978-3-642-82651-1

  • eBook Packages: Springer Book Archive

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