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Epidemiology of Intraocular Melanoma

  • M. A. Tucker
  • P. Hartge
  • J. A. Shields
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 102)

Abstract

Intraocular malignant melanoma (IMM) is a relatively rare tumor, but it affects an estimated 2000 people in the United States yearly. It is the most common primary tumor of the eye in adults (Shields 1983). The incidence of IMM has been studied in descriptive studies of populations and in case reports of individuals and families. Because of the rarity of the disease, few analytic studies have been undertaken. We recently completed a case-control study of 509 IMM patients and equal number of patients with detached retinas seen by Dr. Jerry Shields at the Ocular Oncology Service of the Wills Eye Hospital in Philadelphia. We include preliminary findings from that study in this review.

Keywords

Cutaneous Melanoma Uveal Melanoma Hair Color Choroidal Melanoma Ocular Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

IMM

Intraocular malignant melanoma

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References

  1. Albert DM, Puliafito CA, Fulton AB, et al. (1980) Increased incidence of choroidal melanoma occurring in a single population of chemical workers. Am J Ophthalmol 89: 323–337PubMedGoogle Scholar
  2. Bahn AK, Rosenwaike I, Herrman H, et al. (1976) Melanoma after exposure to PCBs. N Engl J Med 295: 450PubMedGoogle Scholar
  3. Beral V, Rancharan S, Faris R (1977) Malignant melanoma and oral contraceptive use among women in California. Br J Cancer 36: 804–809PubMedCrossRefGoogle Scholar
  4. Bowen SF, Brady H, Jones VL (1964) Malignant melanoma of eye occurring in two successive generations. Arch Ophthalmol 71: 805–806PubMedCrossRefGoogle Scholar
  5. Clark WH Jr, Reimer RR, Greene MH, et al. (1978) Origin of familial melanoma from heritable melanocytic lesions: the B-K mole syndrome. Arch Dermatol 114: 732–738PubMedCrossRefGoogle Scholar
  6. Clark WH Jr, Elder DE, Guerry D, et al. (1984) A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 15: 1147–1165PubMedCrossRefGoogle Scholar
  7. Cutler SJ, Young JL Jr (eds) (1975) Third national cancer survey: incidence data. Nati Cancer Inst Monogr 41Google Scholar
  8. Danforth DN, Russell N, MCBride CM (1982) Hormonal status of patients with primary malignant melanoma: a review of 313 cases. South Med J 75: 661–664PubMedCrossRefGoogle Scholar
  9. Elwood JM, Gallagher RP, Hill GB, et al. (1984) Pigmentation and skin reaction to sun as risk factors for cutaneous melanoma: Western Canada melanoma study. Br Med J 288: 99–102CrossRefGoogle Scholar
  10. Font RL, Reynolds AM, Zimmerman LF (1967) Diffuse malignant melanoma of the iris in the nevus of Ota. Arch Ophthalmol 77: 513–518PubMedCrossRefGoogle Scholar
  11. Gallagher RP, Elwood JM, Rootman J, et al. (1985) Risk factors for ocular melanoma: Western Canada melanoma study. JNCI 74: 775–778PubMedGoogle Scholar
  12. Ganley JP, Comstock GW (1973) Benign nevi and malignant melanomas of the choroid. Am J Ophthalmol 76: 19–25PubMedGoogle Scholar
  13. Gartner S (1940) Malignant melanoma of the choroid and von Recklinghausen’s disease. Am J Ophthalmol 23: 73–78Google Scholar
  14. Green EJ, Hong WK, Everett JR, et al. (1978) Familial intraocular malignant melanoma: a case report. Cancer 41: 2481–2483PubMedCrossRefGoogle Scholar
  15. Greene MH, Sanders RJ, Chu FC, et al. (1983) The familial occurrence of cutaneous melanoma intraocular melanoma, and the dysplastic nevus syndrome. Am J Ophthalmol 96: 238–245PubMedGoogle Scholar
  16. Greene MH, Clark WH Jr, Tucker MA, et al. (1985) Acquired precursors of cutaneous malignant melanoma — the familial dysplastic nevus syndrome. N Engl J Med 312: 91–98PubMedCrossRefGoogle Scholar
  17. Hakulinen T, Tempo L, Saxon E (1978) Cancer of the eye: a review of trends and differentials. World Health Stat Q 31: 143–158PubMedGoogle Scholar
  18. Halasa A (1970) Malignant melanoma in a bilaterial nevus of Ota. Arch Ophthalmol 84: 176–179PubMedCrossRefGoogle Scholar
  19. Harvey EB, Brinton LA (1985) Second cancer following cancer of the breast in Connecticut, 1935–1982. In: Boice JD Jr, Fraumeni JF Jr, Curtis RE, et al (eds) Multiple primary cancer in Connecticut and Denmark. Natl Cancer Inst Monogr 68: 99–112Google Scholar
  20. Heimrich S, Rosenberg L, Shapiro S, et al. (1983) Malignant melanoma and oral contraceptive use. Am J Epidemiol 118: 417 (abstract)Google Scholar
  21. Holly EA, Weiss NS, Liff JM (1983) Cutaneous melanoma in relation to exogeneous hormones and reproductive factors. JNCI 70: 827–831PubMedGoogle Scholar
  22. Holman CDJ, Armstrong BK, Heenan PJ (1983) A theory of the etiology and pathogenesis of human cutaneous melanoma. JNCI 71: 651–656PubMedGoogle Scholar
  23. Jenson O (1963) Malignant melanomas of the uvea in Denmark 1943–1952: a clinical, histopathological and prognostic study. Acta Ophthalmol [Suppl] 75: 1–220Google Scholar
  24. Kedem A, Even-Paz Z, Freund M (1970) Basal cell nevus syndrome associated with malignant melanoma of the iris. Dermatologica 140: 99–106PubMedCrossRefGoogle Scholar
  25. Keller AZ (1973) Histology, survivorship and related factors in the epidemiology of eye cancers. Am J Epidemiol 97: 386–393PubMedGoogle Scholar
  26. Lee JAH (1982) Melanoma In: Schottenfeld D, Fraumeni JF Jr (eds) Cancer epidemiology and prevention. Saunders, Philadelphia, pp 984–993Google Scholar
  27. Lynch HT, Anderson DE, Krush AJ (1968) Heredity and intraocular malignant melanoma. Cancer 21: 119–129PubMedCrossRefGoogle Scholar
  28. Michelson JB, Shields JA (1977) Relationship of iris nevi to malignant melanoma of the uvea. Am J Ophthalmol 83 : 694–696PubMedGoogle Scholar
  29. Morin M, Pickle L, Mason TJ (1984) Geographic patterns of ethnic groups in the United States. Am J Public Health 74: 133–139PubMedCrossRefGoogle Scholar
  30. Mork T (1961) Malignant neoplasms of the eye in Norway: incidence, treatment, and prognosis. Acta Ophthalmol 39: 824–831Google Scholar
  31. Mullaney J, Mooney D, O’Connor M, McDonald GSA (1984) Bilateral ovarian carcinoma with bilateral uveal melanoma. Br J Ophthalmol 68: 261–267PubMedCrossRefGoogle Scholar
  32. Paton D, Thomas LB (1959) Simultaneous occurrence of primary malignant melanomas of the eye and the skin. Arch Ophthalmol 62: 645–652PubMedCrossRefGoogle Scholar
  33. Pfingst AO, Graves S (1921) Melanosarcoma of the choroid occurring in brothers. Arch Ophthalmol 50: 431–439Google Scholar
  34. Raivio I (1977) Uveal melanoma in Finland: an epidemiological, clinical, histological and prognostic study. Acta Ophthalmol [suppl] 133: 1–64Google Scholar
  35. Scotto J, Fraumeni JF, Lee JAH (1976) Melanomas of the eye and other noncutaneous sites: epidemiologic aspects. JNCI 56: 489–491PubMedGoogle Scholar
  36. Shammas HF, Watze RC (1977) Bilateral choroidal melanomas: case report and incidence. Arch Ophthalmol 95: 617–623PubMedCrossRefGoogle Scholar
  37. Shields JA (1983) Introduction to melanocytic tumors of the uvea. In: Shields JA (ed) Diagnosis and management of intraocular tumors. Mosby, St. Louis, pp 65–82Google Scholar
  38. Silcock AO (1892) Hereditary sarcoma of the eyeball in three generations. Br Med J 1: 1079Google Scholar
  39. Strickland D, Lee JAH (1981) Melanomas of eye: stability of rates. Am J Epidemio 1113: 700–702Google Scholar
  40. Swerdlow AJ (1983) Epidemiology of melanoma of the eye in the Oxford region, 1952–78. Br J Cancer 47: 311–313PubMedCrossRefGoogle Scholar
  41. Tasman W (1970) Familial intraocular melanoma. Trans Am Acad Ophthalmol Otolaryngol 74: 955–958PubMedGoogle Scholar
  42. Taylor ME, Guerry D, Bondi EE, et al (1984) Lack of association between intraocular melanoma and cutaneous dysplastic nevi. Am J Ophthalmol 98: 478–482PubMedCrossRefGoogle Scholar
  43. Tucker MA, Shields JA, Hartge P, et al (1985) Sunlight exposure as risk factor for intraocular malignant melanoma. N Engl J Med 313: 789–792PubMedCrossRefGoogle Scholar
  44. Young JL, Percy CL, Asire Ai (eds) (1981) Surveillance, epidemiology an end results: incidence and mortality data 1973–1977. Natl Cancer Inst Monogr 57Google Scholar
  45. Zigman S (1983) The role of sunlight in human cataract formation. Sury Ophthalmol 27: 317–325CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • M. A. Tucker
    • 1
  • P. Hartge
    • 1
  • J. A. Shields
    • 1
  1. 1.National Cancer InsituteBethesdaUSA

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