Thermochemotherapy for Unresectable Hepatic Cancer
The prognosis of unresectable neoplastic disease of the liver, whether primary or metastatic, remains poor. Current methods of treatment are unsatisfactory. The use of standard systemic chemotherapy has resulted in objective tumor responses to 7%–45% of patients so treated [1, 2]. Hepatic artery infusion of chemotherapeutic drugs has allowed for higher response rates of 30%–60% [3–5] but this is an invasive technique and its effect on survival is unclear. Regional radiofrequency hyperthermia (RFHT) has been used to treat deep tumors of the chest, abdomen, and pelvis [6–8] and has been used in combination with hepatic arterial obliteration and intratumor injection of cytotoxic drugs  and in combination with internal radiation .
KeywordsHepatic Malignancy Objective Tumor Response Toronto General Hospital Hepatic Artery Infusion Infusional Chemotherapy
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