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Enhancement of the Effects of 5-Fluorouracil

  • R. Herrmann
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 100)

Abstract

5-Fluorouracil (5-FU) is one of the few anticancer agents that has been developed on a rational basis [10]. Although it has been clinically used since the late 1950s, 5-FU has recently attracted new interest because of two developments:
  1. 1.

    Methods have been developed which allow the detection of small amounts of 5-FU and most of its metabolites.

     
  2. 2.

    There has been a revival of regional drug administration, especially hepatic artery infusion. Since 5-FU is metabolized in the liver to a significant degree, it is one of the drugs used for this administration.

     

Keywords

Clin Oncol L1210 Cell Sequential Combination Thymidylate Synthetase Hepatic Artery Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • R. Herrmann
    • 1
  1. 1.Medizinische KlinikKlinikum Charlottenburg der Freien UniversitätBerlin 19Germany

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