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Indications for Treatment and Determination of Treatment Effects with Primary and Secondary Liver Tumors

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 100))

Abstract

Recent developments in operative and pharmacological techniques for locoregional treatment of liver malignancies have focused the interest of oncologists on this organ. With respect to indication for treatment and determination of treatment effects of systemic chemotherapy in liver tumors, a number of questions may be formulated:

  1. 1.

    Is there anything specific in malignant liver disease as compared with involvement of other organs?

  2. 2.

    Does liver involvement modify the indication or results of systemic treatment used in disseminated cancer?

  3. 3.

    Is the determination of treatment effects in disseminated cancer influenced by liver involvement?

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References

  1. Buroker T, Moertel C, Fleming T, Everson L, Cullinan S, Krook U, Foley J, Schutt A (1984) A randomized comparison of 5-FU containing drug combinations with 5-FU alone in advanced colorectal carcinoma. Abstract C-537. Proc Am Soc Clin Oncol 3: 138

    Google Scholar 

  2. Chabner BA, Myers CE (1982) Clinical pharmacology of cancer chemotherapy. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of oncology. Lippincott, Philadelphia

    Google Scholar 

  3. Cullinan S, Moertel C, Fleming T, Everson L, Krook J, Schutt A (1984) A randomized comparison of 5-FU alone (F), 5-FU + adriamycin (FA) and 5-FU + adriamycin + mitomycin C (FAM) in gastric and pancreatic cancer. Abstract C-536. Proc Am Soc Clin Oncol 3: 137

    Google Scholar 

  4. Dombernowsky P, Hirsch F, Hansen HH, Hainau B (1978) Peritoneoscopy in the staging of 190 patients with small-cell anaplastic carcinoma of the lung with special reference to subtyping. Cancer 41: 2008–2012

    Article  PubMed  CAS  Google Scholar 

  5. George SL, Hoogstraten B (1978) Prognostic factors in the initial response to therapy by patients with advanced breast cancer. J Natl Cancer Inst 60: 731–736

    PubMed  CAS  Google Scholar 

  6. Havelaar IJ, Sugarbaker PH, Vermess M, Miller DL (1984) Rate of growth of intraabdominal metastases from colorectal cancer. Cancer 54: 163–171

    Article  PubMed  CAS  Google Scholar 

  7. Ihde DC, Makuch RW, Carney DN, Bunn PA, Cohen MH, Matthews MJ, Minna JD (1981) Prognostic implication of sites of metastases in patients with small cell carcinoma of the lung given intensive combination chemotherapy. Am Rev Respir Dis 123: 500–507

    PubMed  CAS  Google Scholar 

  8. Kemeny N (1983) The systemic chemotherapy of hepatic metastases. Semin Oncol 10: 148–158

    PubMed  CAS  Google Scholar 

  9. Metzger U, Mermillod B, Aeberhard P, Egeli R, Laffer U, Martinoli S, Mueller W, Schroeder R, Cavalli F, Weber W (1984) Adjuvant portal liver infusion with 5-fluorouracil and mitomycin C following curative large bowel cancer surgery. In: Jones SE, Salmon SE (eds)Adjuvant therapy of cancer I V. Grune and Stratton, New York

    Google Scholar 

  10. Peto R (1978) Clinical trial methodology. Biomedicine 28: 24–36

    PubMed  Google Scholar 

  11. Pikren JW, Tsukuda Y, Lane WW (1984) Liver metastases: analysis of autopsy data In: Weiss L, Gilbert HA (eds) Liver metastases. Hall, Boston

    Google Scholar 

  12. Pontes JE, Wajsman Z, Beckley S, Williams P, Murphy GP (1983) The treatment of stage III nonseminomatous testicular tumors. Cancer 51: 1327–1331

    Article  PubMed  CAS  Google Scholar 

  13. Porzsolt F, Schreml W, Mende S, Buchelt L, Knöchelmann R, Brass B, Gerteis D, Stier R (1984) A phase IV protocol for treatment of metastatic breast cancer. Abstract 5/8 GL. J Cancer Res Clin Oncol [Suppl] 107: 12

    Google Scholar 

  14. Reynolds TF, Vugrin D, Cvitkovic E, Cheng E, Braun DW, O’Hehir MA, Dukeman ME, White-more WF, Golbey RB (1981) VAB-3 combination chemotherapy of metastatic testicular cancer. Cancer 48: 888–898

    Article  PubMed  CAS  Google Scholar 

  15. Samson MK, Fisher R, Stephens RL, Rivkin S, Opipari M, Maloney T, Groppe CW (1980) Vinblastine, bleomycin and cis-diaminodichloroplatinum in disseminated testicular cancer: response to treatment and prognostic correlations. Eur J Cancer 16: 1359–1366

    Article  PubMed  CAS  Google Scholar 

  16. Sauer H (1983) Beeinflussung der Wirkung von Zytostatika. In: Drings P, Schreml W (eds) Supportive Maßnahmen bei der Internistischen Tumorbehandlung. Zuckschwerdt, München, p I75–197

    Google Scholar 

  17. Schreiber C (1984) Metastasen bei unbekanntem Primärtumor. Dissertation, Ulm

    Google Scholar 

  18. Schreml W (1985) Adjuvante Therapie gastrointestinaler Tumoren - gegenwärtiger Stand. Der informierte Arzt (in press)

    Google Scholar 

  19. Schreml W, Porzsolt F, Brass B (1985) Telefonische Beratungsstelle des Tumorzentrums Ulm - Bericht über 6 Jahre Tätigkeit. Munch Med Wschr (in press)

    Google Scholar 

  20. Seeber S, Schütte J, Niederle N, Schmidt CG (1983) Neue Ergebnisse der Behandlung metastasierender Hodentumoren im Früh-und Spätstadium. Tumor Diagn Ther 4: 45–54

    Google Scholar 

  21. Taylor J, Mullee MA, Machin D (1984) Adjuvant therapy of colorectal cancer with portal vein cytotoxic perfusion. In: Jones SE, Salmon SE (eds) Adjuvant therapy of cancer I V. Grune and Stratton, New York

    Google Scholar 

  22. Ultmann JE, Phillips TL (1982) Management of the patient with cancer of unknown primary site. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer. Principles and practice of Oncology. Lippincott, Philadelphia

    Google Scholar 

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© 1986 Springer-Verlag Berlin · Heidelberg

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Schreml, W. (1986). Indications for Treatment and Determination of Treatment Effects with Primary and Secondary Liver Tumors. In: Herfarth, C., Schlag, P., Hohenberger, P. (eds) Therapeutic Strategies in Primary and Metastatic Liver Cancer. Recent Results in Cancer Research, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82635-1_12

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  • DOI: https://doi.org/10.1007/978-3-642-82635-1_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82637-5

  • Online ISBN: 978-3-642-82635-1

  • eBook Packages: Springer Book Archive

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