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Antigenpräsentation

  • Klaus Wolff
  • G. Stingl
Conference paper
Part of the Der Hautarzt book series (VDGDERMATOLOGIE, volume 34)

Zusammenfassung

Die Entwicklung einer Immunantwort auf Kontaktallergene setzt die zelluläre Kollaboration lymphoider und Antigen-präsentierender Zellen (APZ; Macrophagen oder dendritische Zellen) voraus. Um eine Immunantwort auszulösen, muß das Antigen durch APZ jungfräulichen T-Lymphozyten präsentiert werden, wobei nach Erkennung, Aufnahme und Verarbeitung des nominalen Antigens (processing) dieses zusammen mit einem an der Oberfläche des APZ exprimierten Klasse II Alloantigen (la Antigen) dem T-Lymphozyten präsentiert wird und diesen zur Proliferation anregt [13, 22]. Nach dem derzeitigen Stand des Wissens ist bei diesem Vorgang eine zelluläre Interaktion zwischen APZ und T-Zelle notwendig; gleichzeitig setzt die APZ ein Monokin frei (Interleukin I) [10], das als zweites Signal den immunogenen Stimulus verstärkt [25].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Klaus Wolff
    • 1
  • G. Stingl
    • 1
  1. 1.Universitäts-HautklinikWienAustria

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