Skip to main content

Part of the book series: Der Hautarzt ((VDGDERMATOLOGIE,volume 34))

  • 28 Accesses

Zusammenfassung

Man unterscheidet zu Recht exogene und endogene Risikofaktoren, die bei der Entstehung maligner Melanome eine Rolle spielen oder spielen könnten. Als exogene Faktoren kommen Alter, Geschlecht und hormoneile Kontrazeption in Frage, aber auch die exogene Belastung durch UV-Bestrahlung und diejenige durch Umwelt-Karzinogene [8, 10]. Das Pigmentkleid (homogen oder inhomogen) und die Pigmentierungsmöglichkeiten spielen wichtige Rollen zum adaptiven Schutz vor Exzessen der exogenen UV-Belastung der Haut. Der exogenen Belastbarkeit und der Anfälligkeit der menschlichen Haut zur Entstehung maligner Melanome liegen zudem endogene Faktoren zugrunde, deren Erfassung, Messung und Beeinflussung wesentliche Voraussetzungen zur Prävention maligner Melanome darstellen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  1. Bernstein MJ (1984) Precursors to malignant melanoma. J Am Med Ass 251:1864–1866

    Article  Google Scholar 

  2. Fischer E, HW Thielmann, B Neundörfer, FJ Rentsch, L Edler, EG Jung (1982) Xeroderma pigmentosum patients from Germany: clinical symptoms and DNA repair characteristics. Arch Dermatol Res 274:229–247

    Article  PubMed  CAS  Google Scholar 

  3. Gartmann H (1984) Was sind dysplastische Nävi? Hautarzt 35:3–6

    PubMed  CAS  Google Scholar 

  4. Greene MH (1983) Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rhlocus. Proc Natl Acad Sci USA 80:6071–6075

    Article  PubMed  CAS  Google Scholar 

  5. Happle R (1982) Arguments in favor of a polygenic inheritance of precursor nevi. J Am Acad Dermatol 6:540–543

    Article  PubMed  CAS  Google Scholar 

  6. Howell IN, MH Greene, RC Corner, VM Maher, JJ McCormick (1984) Fibroblasts from patients with hereditary cutaneous malignant melanoma are abnormally sensitive to the mutagenic effect of simulated sunlight and 4-nitroquinoline I-oxide. Proc Natl Acad Sci USA 81:1179–1183

    Article  PubMed  CAS  Google Scholar 

  7. Jung EG, E Bohnert, E Fischer (in press) Heterogeneity of xeroderma pigmentosum (XP); variability and stability within and between the complementation groups C, D, E, 1 and variants. Photodermatology

    Google Scholar 

  8. Kopf AW, MK Kripke, RS Stern (1984) Sun and malignant melanoma. J Am Acad Dermatol 11:674–684

    Article  PubMed  CAS  Google Scholar 

  9. Kraemer KH (1983) Dysplastic nevi and cutaneous melanoma risk. Lancet 2:1076–1077

    Article  PubMed  CAS  Google Scholar 

  10. MacKie RM (ed) (1983) Malignant Melanoma. Karger, Basel

    Google Scholar 

  11. Patton JD, LA Rowan, AL Mendrala, IN Howell, VM Maher, JJ McCormick (1984) Xeroderma pigmentosum fibroblasts including cells from XP variants are abnormally sensitive to the mutagenic and cytotoxic action of broad spectrum simulated sunlight. Photochemistry and Photobiology 39:37–42

    Article  PubMed  CAS  Google Scholar 

  12. Ramsay RG, P Chen, FP Imray, C Kidson, MF Lavin, A Hockey (1982) Familial melanoma associated with dominant ultraviolet radiation sensitivity. Cancer Res 42:2909–2912

    PubMed  CAS  Google Scholar 

  13. Smith PJ, MH Creene, DA Devlin, EA McKeen, MC Paterson (1982) Abnormal sensitivity to UV-radiation in cultured skin fibroblasts from patients with hereditary cutaneous malignant melanoma and dysplastic nevus syndrome. Int J Cancer 30:39–45

    Article  PubMed  CAS  Google Scholar 

  14. Smith PJ, MH Greene, D Adams, MC Paterson (1983) Abnormal responses to the carcinogen 4-nitroquinoline I-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma. Carcinogenesis 4:911–916

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Jung, E.G. (1986). Risikofaktoren der Entstehung maligner Melanome. In: Schnyder, U.W., Wüthrich, B., Eichmann, A. (eds) Verhandlungen der Deutschen Dermatologischen Gesellschaft. Der Hautarzt, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82597-2_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-82597-2_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15844-8

  • Online ISBN: 978-3-642-82597-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics