Alcohol, Tobacco and Oesophageal Cancer: An International Comparison

  • P. Ghadirian
  • J.-P. Thouez
Part of the Medicolegal Library book series (MEDICOLEGAL, volume 6)


Numerous case-control studies have been carried out in different parts of the world regarding the role of alcohol in the development of oesophageal cancer. Since at least in the West, heavy drinkers are frequently smokers and inasmuch as several studies have indicated that the combination of alcohol and tobacco has a higher risk than the use of either substance alone, the best studies are those which permit assessment of both the independent and the combined effect of these two factors. All evidence concerning both alcohol and tobacco is considered together in this chapter.


Alcoholic Beverage Heavy Drinker Oesophageal Cancer Tobacco Consumption Male Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ahmed N (1966) Geographical incidence of oesophageal cancer in west Kenya. East African Med J 43 /7: 235–248Google Scholar
  2. 2.
    Bradshaw E, Schonland E (1969) Oesophageal and lung cancer in natal African males in relation to certain socioeconomic factors. Ananalysis of 484 interviews. Br J Cancer 23: 275–284CrossRefGoogle Scholar
  3. 3.
    Cheng PCL (1949) Carcinoma of the oesophagus. A statistical study of 43 cases. Chinese Med J 67: 662–667Google Scholar
  4. 4.
    Chilvers C, Fraser P, Beral V (1979) Alcohol and oesophageal cancer: an assessment of the evidence from routinely collected data. J Epidemiological and Community Health 33: 127–133CrossRefGoogle Scholar
  5. 5.
    Collis LH, Cook PJ, Foreman JK, Palframan (1972) Cancer of the oesophagus and alcoholic drink in East Africa. Lancet, February 19Google Scholar
  6. 6.
    Cook P (1971) Cancer of the oesophagus in Africa. Br J Cancer 25: 853–880CrossRefGoogle Scholar
  7. 7.
    Cook-Mozaffari PJ Personal communicationGoogle Scholar
  8. 8.
    De Jong VW, Breslow N, Goh Ewe Long J, Sridharan M, Sharnmuggarathnam K (1974) Aetiological factors in oesophageal cancer in Singapore. Chinese Int J Cancer 13: 291–303CrossRefGoogle Scholar
  9. 9.
    Doll R (1971) Oesophageal cancer: a preventable disease? In: International seminar of the epidemiology of oesophageal cancer: Indian Cancer Society and UICCGoogle Scholar
  10. 10.
    Doll R, Hill AB (1952) A study of the aetiology of carcinoma of the lung. Br Med J 2: 1271–1286CrossRefGoogle Scholar
  11. 11.
    Doll R, Peto R (1976) Mortality in relation to smoking: 20 years observation on male British doctors. Br Med J December25, 1525–1536Google Scholar
  12. 12.
    Flamant R, Lasserne O, Lazar P, Leguerinais J, Denoix P, Schwartz D (1964) Differences in sex-ratio according to cancer site and possible relationship with use of tobacco and alcohol: review of 65000 cases. J Natl Cancer Inst 32 /6: 1309–1314Google Scholar
  13. 13.
    Ganeshananthan N (1975) Aetiological aspects of oesophageal carcinoma in Sri Lanka. Ceylon Med J 4–19Google Scholar
  14. 14.
    Hakulinen T, Lehtimaki L, Lehtonen M, Teppo L (1974) Cancer mortality among two male cohorts with increased alcohol consumption in Finland. J Natl Cancer Inst 52: 1711–1714Google Scholar
  15. 15.
    Hiramaya T (1971) An epidemiological study of cancer of the oesophagus in Japan, with special reference to the combined effort of selected environmental factors. Monograph No.1, Int seminar on epidemiology of oesophageal cancer, Bangolor, India, November 4, pp 45–60Google Scholar
  16. 16.
    International Agency for Research on Cancer (IARC). Annual Report, Lyon, 1975Google Scholar
  17. 17.
    International Agency for Research on Cancer (IARC). Annual Report, Lyon, 1976Google Scholar
  18. 18.
    Jayant K, Balak, Shnor V, Sanghvi CD, Jussawalla DJ (1977) Quantification of the role of smoking and chewing tobacco in oral, pharyngeal and oesophageal cancers. Br J Cancer 35: 232–235CrossRefGoogle Scholar
  19. 19.
    Joint IRAN/IARC Study Group (1977) Oesophageal cancer studies in the Gaspian Littoral of Iran: results of population studies. A Prodrome. J Natl Cancer Inst 59 /4: 1127–1138Google Scholar
  20. 20.
    Kmet J Personal CommunicationGoogle Scholar
  21. 21.
    Kolicheva NI (1980) Epidemiology of oesophageal cancer in the USSR. In: Levin DL (ed) Cancer epidemiology in the USA and USSR. Department of Health and Human Services, Washington, NIH Publications no 80–2044, 191–197Google Scholar
  22. 22.
    Kwan KW (1937) Carcinoma of the oesophagus. Chines Med J 52: 237–254Google Scholar
  23. 23.
    Lambert R, Audigier JC, Tuyns A (1978) Epidemiology of oesophageal cancer in France. Carcinoma of the oesophagus, Cape Town, South AfricaGoogle Scholar
  24. 24.
    Li KH, Kao IC, Wu YK (1962) A survey of carcinoma of the oesophagus in North-China. Chinese Med J 81: 489–494Google Scholar
  25. 25.
    Mahboubi E, Day NE, Ghadirian P, Salmasizadeh S (1977) Negligible role of alcohol and tobacco in the aetiology of oesophageal cancer. Cancer Detection and Prevention 2: 1149–1159Google Scholar
  26. 26.
    Martinez I (1969) Factors associated with cancer of the oesophagus, mouth and pharynx in Puerto Rico. J Natl Cancer Inst 42: 1069–1094Google Scholar
  27. 27.
    McGlashan ND (1967) Zinc and oesophageal cancer. Lancet, Nov 9Google Scholar
  28. 28.
    McGlashan ND (1975) Food contaminants and oesophageal cancer. McThuen, LondonGoogle Scholar
  29. 29.
    McGlashan ND, Walter CL, McLean AEM (1968) Nitrosamines in African alcohol spirits and oesophageal cancer. Lancet, Nov 9Google Scholar
  30. 30.
    McGlashan ND, Patterson RLS, Williams AA (1970) N-Nitrosamines and grain-based spirits. Lancet 2: 1138CrossRefGoogle Scholar
  31. 31.
    Mohankumar K, Ramachandran P, Haridas KP (1971) Carcinoma of the oesophagus: a study of 103 cases (part one). Indian J Med Sci 25: 705–711Google Scholar
  32. 32.
    Pottern LM, Morris LE, Blat WJ, Ziegler RG, Fraumeni JF (1981) Oesophageal cancer among black men in Washington, D.C. 1-alcohol, tobacco and other risks factors. JNCI 67: 777–783Google Scholar
  33. 33.
    Sanghvi CD, Rao KCM, Knolker VR (1955) Smoking and chewing of tobacco in relation to cancer of the upper alimentary tract. Br Med J 7: 111–114Google Scholar
  34. 34.
    Schwartz D, Lellouch J, Flamant R, Denoix PF (1962) Alcohol et cancer. Résultats d’une enquête rétrospective. Rev Fr Études Clin Biol 7: 590–604Google Scholar
  35. 35.
    Sobin LH (1969) Cancer in Afganistan. Cancer 23Google Scholar
  36. 36.
    Steiner P (1956) Aetiology and histogenesis of carcinoma of oesophagus. Cancer 9: 436–452CrossRefGoogle Scholar
  37. 37.
    Stephen SJ, Uragoda CG (1970) Some observations on oesophageal carcinoma in Ceylon, including the relationship to betel chewing. Br J Cancer 24Google Scholar
  38. 38.
    Theurer RC, Vitale JJ (1976) Drug and nutrient interactions. In: C. E. Anderson, D. B. Coursin, H. A. Schneider (eds) Nutritional support for medical practice. Harper and Row, New YorkGoogle Scholar
  39. 39.
    Tuyns AJ, Audigier JC (1976) Double wave cohort incidence for oesophageal and laryngeal cancer in France in relation to reduce alcohol consumption during the Second World War. Digestion 14: 197–208CrossRefGoogle Scholar
  40. 40.
    Tuyns AJ, Pequignat G, Jensen OM (1977) Le cancer de l’oesophage en Ille et Vilaine en fonction des niveaux de consommation d’alcohol et de tabac. Des risques qui se multiplient. Bull Cancer 64: 45–60Google Scholar
  41. 41.
    Tyuns Ai, Pequignat G, Abbatucci JS (1979) Oesophageal cancer and alcohol consumption. Importance of type of beverage. Int J Cancer 23: 443–447Google Scholar
  42. 42.
    Van Rensburg J (1978) The effect of food, beer and snuff. Carcinoma of the oesophagus. Cape Town, South AfricaGoogle Scholar
  43. 43.
    Vitale JJ, Coffey J (1971) Alcoholism and vitamin metabolism. In: Kissin B, Begleiter M (eds) Biochemistry. Plenum, New York, p 327Google Scholar
  44. 44.
    Wu YK, Laucks HH (1951) Carcinoma of the oesophagus or cardia of the stomach. Ann Surg 134: 946–956CrossRefGoogle Scholar
  45. 45.
    Wynder EL, Lemon FR, Bross IJ (1959) Cancer and Coronary artery disease among Seventh Day Adventists cancer, 5 /12: 1016–1028Google Scholar
  46. 46.
    Wynder EL, Bròss IJ (1961) A study of aetiological factors in cancer of the oesophagus. Cancer 14: 389–413CrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • P. Ghadirian
  • J.-P. Thouez

There are no affiliations available

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