Untersuchung der Proteinsynthese

  • Wolf-Dieter Heiss
  • Curt Beil
  • Karl Herholz
  • Günter Pawlik
  • Rainer Wagner
  • Klaus Wienhard

Zusammenfassung

Die Proteinsynthese ist — anders als die metabolische Rate für Glukose und Sauerstoff, die Durchblutung und das Blutvolumen — nur geringgradig vom funktionellen Zustand des Gehirngewebes abhängig, sondern steht wahrscheinlich in Beziehung zu über längere Zeit wirkenden Beeinflussungen der Hirntätigkeit, z.B. Lernen und Gedächtnis, Entwicklung und Plastizität des Gehirns. In Änderungen der Proteinsynthese lassen sich evtl. frühzeitig pathologische Prozesse, z.B. degenerative und neoplastische Erkrankungen, fassen. Wirkungen von Medikamenten und Hormonen und Reparations- und Regenerationsmechanismen nach Verletzungen oder Erkrankungen können darin ihren Ausdruck finden.

Investigation of Protein Synthesis

Abstract

Protein synthesis, in contrast to the metabolic rate for glucose and oxygen, blood flow, and blood volume, depends only to a small degree on the functional state of the cerebral tissue, and is probably related to influences on the brain activity, such as learning and memory, development, and plasticity of the brain, which act over a prolonged period. Changes in protein synthesis may allow the detection of early pathologic processes, such as degenerative and neoplastic diseases, and may also reflect the effects of drugs and hormones and of repair and regeneration mechanisms after injuries of illnesses.

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Literatur References

  1. Barrio JR, Keen R, Chugani H, Ackerman R, Chugani DC, Phelps ME (1983a) L-(1-C-11)phenylalanine for the determination of cerebral protein synthesis rates in man with positron emission tomography. J Nucl Med 24:P70Google Scholar
  2. Barrio JR, Keen RE, Ropchan JR, MacDonald NS, Baumgartner FJ, Padgett HC, Phelps ME (1983b) L-(111C)Leucine: Routine synthesis by enzymatic resolution. J Nucl Med 24:515–521Google Scholar
  3. Bergström M, Collins VP, Ehrin E et al. (1983) Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using (68GA)EDTA, (11C)glucose, and (11C)methionine. J Comput Assist Tomogr 7: 1062–1066PubMedCrossRefGoogle Scholar
  4. Bustany P, Henry JF, Sargent T, Zarifian E, Cabanis E, Collard P, Comar D (1983) Local brain protein metabolism in dementia and schizophrenia: in vivo studies with 11C-Lmethionine and positron emission tomography. In: Heiss WD, Phelps ME (eds) Positron emission tomography of the brain. Springer, Berlin Heidelberg New York, pp 208–211Google Scholar
  5. Bustany P, Henry JF, Rotrou J de et al. (1985) Correlations between clinical state and positron emission tomography measurement of local brain protein synthesis in Alzheimer’s dementia, parkinson’s disease, schizophrenia, and gliomas. In: Greitz T, Ingvar DH, Widén L (eds) The metabolism of the human brain studied with positron emission tomography. Raven, New York, pp 241–249Google Scholar
  6. Comar D, Cartron JC, Maziere M, Moranzano C (1976) Labeling and metabolism of methionine-methyl-11C. Eur J Nucl Med 1:11–14PubMedCrossRefGoogle Scholar
  7. Fowler JS, Wolf AP (1982) Synthesis of carbon-11, fluoride-18 and nitrogen-13 labeled radiotracers for biomedical applications. NAS-NS 3101, Nat Acad Sci, Nat Res Counc, Nat Techn Inform SeryGoogle Scholar
  8. Phelps ME, Barrio JR, Huang SC, Keen RE, Chugani H, Mazziotta JC (1984) Criteria for the tracer kinetic mea-surement of cerebral protein synthesis in humans with positron emission tomography. Ann Neurol 15 [Suppl]:S192–5202PubMedCrossRefGoogle Scholar
  9. Smith CB, Davidsen L, Deibler G et al. (1980) A method for the determination of local rates of protein synthesis in brain. Trans Am Soc Neurochem 11:94Google Scholar
  10. Washburn LC, Sun TT, Byrd BL et al. (1979) High-level production of 11C carboxyl-labeled amino acids. In: Sorenson JA (ed) Radiopharmaceuticals. Society of Nuclear Medicine, New York, pp 767–777Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Wolf-Dieter Heiss
    • 1
  • Curt Beil
    • 1
  • Karl Herholz
    • 1
  • Günter Pawlik
    • 1
  • Rainer Wagner
    • 1
  • Klaus Wienhard
    • 1
  1. 1.Max-Planck-Institut für neurologische ForschungKöln 91(Merheim)Deutschland

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