Zusammenfassung
Als Alternativen zur Durchblutungsmessung unter Verwendung von 15O können Krypton-77 und mit Fluor-18-markiertes Fluormethan (CH3 18F) eingesetzt werden. Es handelt sich um inerte Gase, die kurze Zeit über ein geschlossenes Atemsystem inhaliert werden. Eine Quantifizierung in Absolutwerten ist ohne arterielle Blutentnahmen möglich, und beide Isotope erlauben aufgrund ihrer relativ langen Halbwertzeit Transporte bis zu ca. 1 h Dauer. Als weiterer Tracer kommt 13NH3 in Betracht, der jedoch nur die Durchblutungsverteilung wiedergeben kann. Eine Quantifizierung ist nur mit Einschränkungen möglich.
Abstract
As alternatives to blood flow measurement with oxygen-15, krypton-77 and fluoromethane labeled with fluorine-18 (CH3 18F) can be used. These are inert gases, and are inhaled for short time through a closed respiration system. A quantification in absolute values is possible without arterial blood sampling, and both isotopes, because of their relatively long half-life, allow transport times of up to about 1 h. 13NH3 can also be considered as a tracer, although it can only show the blood flow distribution. Quantification is only possible to a limited degree.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur References
Diksic M, Galinier JL, Marshall H, Yaffe L (1979) Preparation of carrier-free Kr by (p, xn) reactions on natural bromine. Int J Appl Radiat Isot 28:885–888
He Y, Qaim SM, Stöcklin G (1982) Excitation functions for 3He-particle induced nuclear reactions on 76Se, 77Se and “’Se: Possibilities of production of ”Kr. Int J Appl Radiat Isot 33:13–19
Holden JE, Gatley SJ, Hichwa RD, Ip WR, Shaughnessy WJ, Nickles RJ, Polcyn RE (1981) Cerebral blood flow using PET measurements of fluoromethane kinetics. J Nucl Med 22:1084–1088
Gatley SJ, Hichwa RD, Shaughnessy WJ, Nickles RJ (1981) 18F-labeled lower fluoro alkanes: Reactor-produced gaseous physiological tracers. Int J Appl Radiat Isot 32:211–214
Koeppe RA, Holden JE, Polcyn RE, Nickles RJ, Gutchins GD, Weese JL (1985) Quantitation of local cerebral blood flow and partition coefficient without arterial sampling: Theory and validation. J Cereb Blood Flow Metab 5:214–223
Kuhl DE, Phelps ME, Howell AP, Metter EJ, Selin C, Winter J (1980) Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and “NH3. Ann Neurol 8:47–60
Phelps ME, Huang SC, Hoffman EJ, Selm C, Kuhl DE (1981) Cerebral extraction of N-13 ammonia: Its dependence on cerebral blood flow and capillary permeability — surface area product. Stroke 12:607–619
Straatmann MG (1977) A look at 13N and 150 radiopharmaceuticals. Int J Appl Radiat Isot 28:13–20
Wagner R (1984) A fast, high-yield synthesis of 18F-fluoromethane from 18F-F2. J Lab Comp Radiopharm 21:1229–1230
Yamamoto YL, Thompson CJ, Meyer E, Robertson JS, Fein-del W (1977) Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr. J Comput Assist Tomogr 1:43–56
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Heiss, WD., Beil, C., Herholz, K., Pawlik, G., Wagner, R., Wienhard, K. (1985). Andere Verfahren zur Durchblutungsmessung. In: Atlas der Positronen-Emissions-Tomographie des Gehirns / Atlas of Positron Emission Tomography of the Brain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82566-8_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-82566-8_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82567-5
Online ISBN: 978-3-642-82566-8
eBook Packages: Springer Book Archive