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Naloxonbehandlung der Alkoholvergiftung — Aspekte zur biologischen Theorie des Alkoholismus

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Book cover Biologie der Sucht

Part of the book series: Suchtproblematik ((SUCHT))

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Zusammenfassung

Von einer Naloxonapplikation bei akuter Alkoholvergiftung wird zunächst ein wirksamer Antagonismus gegenüber der vital gefährdenden Intoxikationssymptomatik erhofft. Der möglichen Interaktion biochemischer Alkoholeffekte mit dem reinen Morphinantagonisten Naloxon kommt darüber hinaus eine besondere Bedeutung für die Theorienbildung innerhalb der biologischen Alkoholforschung zu. In diesem Zusammenhang haben der experimentelle Nachweis alkaloider Kondensationsprodukte zwischen biogenen Aminen und Azetaldehyd — sog. Tetraisochinoline — sowie die Erforschung endogener Opioide — eingeleitet mit der Entdeckung der Opiatrezeptoren [67, 76, 78], der Identifikation von Enkephalinen [42] und der Isolation von Endorphinen [31] — unseren Kenntnisstand über die möglichen biologischen Wirkmechanismen von Alkoholrausch und -abhängigkeit entscheidend gefördert.

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Schenk, G.K. (1985). Naloxonbehandlung der Alkoholvergiftung — Aspekte zur biologischen Theorie des Alkoholismus. In: Biologie der Sucht. Suchtproblematik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82542-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-82542-2_9

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  • Print ISBN: 978-3-540-15560-7

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