Abstract
Calcitonin (CT), a calcium-regulating peptide, is eutopically produced in patients with medullary carcinoma of the thyroid and ectopically by a number of nonthyroid tumors. Ectopic production of human calcitonin (hCT) has been found mainly in carcinoma of the lung (Silva et al. 1974; Gropp et al. 1980), breast cancer (Coombes et al. 1974), pheochromocytoma (Milhaud et al. 1974), and islet cell tumors of the pancreas (Milhaud et al. 1974; Deftos et al. 1975). Apart from C cell carcinoma it is only in lung cancer that immunoreactive hCT has been found to be elevated in high frequency and in these tumors hCT has been used as a tumor marker to monitor therapy (Gropp et al. 1980). Besides the hCT another calcitonin, the salmon calcitonin (sCT), has been detected in such animals as eel, salamander, chicken, pigeon, and rat (Perez Cano et al. 1981, 1982). In these animals human and salmon calcitonin can be detected simultaneously. Recently Fischer et al. (1983) have described sCT also in human thyroid glands and in human brain. In this paper a more detailed analysis of hCT present in sera, tissue extracts, and supernatants of permanent lung cancer cell lines is presented. Furthermore, initial data on the determination of sCT in lung cancer are described.
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References
Coombes RC, Hillyard C, Grennberg PB, MacIntyre I (1974) Plasma immunoreactive calcitonin in patients with non-thyroid tumors. Lancet 1: 1080–1083.
Deftos LJ, Ross BA, Bronzent D, Parthemore JG (1975) Immunochemical heterogeneity of calcitonin in plasma. J Clin Endocrinol Metab 40: 409–412.
Desplan C, Benicourt C, Jullienne A, et al. (1980) Cellfree translation of mRNS coding for human and murine calcitonin. FEBS Lett 117: 89–92.
Fischer JA, Tobler PH, Henke H, Ischopp FA (1983) Salmon and human calcitonin-like peptides coexist in the human thyroid and brain. J Clin Endocrinol Metab 57: 1314–1316.
Goldstein IJ, Hollerman CE, Smith EE (1965) Proteincarbohydrate interaction. II. Inhibition studies on the interaction of concavalin A with polysaccharides. Biochemistry 4: 876–883.
Goltzman D, Tischler AS (1978) Characterization of calcitonin released by medullary thyroid carcinoma in tissue culture. J Clin Invest 61: 449–458.
Gropp C, Havemann K, Scheuer A (1980) Ectopic hormones in lung cancer patients at diagnosis and during therapy. Cancer 46: 347–354.
Hjelm H, Hjelm K, Sjöquist J (1972) Protein A from Staphylococcus aureus, its isolation by affinity chromatography and its use as immunosorbent for isolation of immunoglobulins. FEBS Lett 28: 73–76.
Jacobs JW, Lund PK, Potts JT, Jr, Bell NH, Habener JF (1981) Procalcitonin is a glycoprotein. J Biol Chem 256: 2803–2807.
Luster W, Gropp C, Sostmann H, Kalbfleisch H, Havemann K (1982) Demonstration of immunoreactive calcitonin in sera and tissues of lung cancer patients. Eur J Cancer Clin Oncol 18: 1275–1283.
Luster W, Gropp C, Kern HF, Havemann K (1984) Biosynthesis of hormone immunoreactive proteins by non-small cell lung tumor cells in vitro. Acta Endocrin 105: [Suppl] 264: 55–56.
Milhaud G, Calmette C, Taboulet J, Julienne A, Moukhtar MS (1974) Hypersecretion of calcitonin in neoplastic conditions. Lancet I: 462–463.
Perez Cano R, Galan Galan F, Girgis SI, Arnett TR, MacIntyre I (1981) A human calcitonin-like molecule in the ultramobranchial body of the amphibia (Rana pipiens). Expeientia 37: 1116–1117.
Perez Cano R, Girgis SI, Galan Galan F, MacIntyre I (1982) Identification of both human and salmon calcitonin-like molecules in birds suggesting the existence of two calcitonin genes. J Endocrinol 92: 351–355.
Silva OL, Becker KL, Primack A, Doppmann I, Snider RH (1974) Ectopic section of calcitonin by oat-cell carcinoma. N Engl J Med 290: 1122–1124.
Weber K, Osborn M (1969) The reliability of molecular weight determination by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem 244: 4406–4412.
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© 1985 Springer-Verlag Berlin Heidelberg
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Gropp, C., Luster, W., Havemann, K. (1985). Calcitonin in Lung Cancer. In: Havemann, K., Sorenson, G., Gropp, C. (eds) Peptide Hormones in Lung Cancer. Recent Results in Cancer Research, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82533-0_9
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DOI: https://doi.org/10.1007/978-3-642-82533-0_9
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