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Oncogene Expression in Human Small Cell Lung Carcinoma

  • Conference paper
Peptide Hormones in Lung Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 99))

Abstract

We have recently reviewed the potential dynamics of cellular differentiation in the bronchial epithelium of man, which underly the evolution of the four major types of lung cancer (squamous cell, adeno-, large cell undifferentiated, and small cell carcinomas) and which determine how the tumor types express properties characteristic of particular differentiated cell types in the normal mucosa (Baylin 1983, 1984; Goodwin et al. 1983). The accumulating evidence that small cell lung carcinoma (SCLC), which accounts for 25% of human lung cancers and is a distinct, aggressive neoplasm with neuroendocrine properties, is linked by way of a common cell lineage to the non-SCLC lung tumors has also been stressed (Baylin 1983, 1984; Goodwin et al. 1983). Particular importance in this regard attaches to the in vitro data suggesting the potential of SCLC to change towards other lung cancer histologies with time (Baylin 1983, 1984; Goodwin et al. 1983; Gazdar et al. 1981a). An important transition step in this process may involve a variant cell form (SCLC-V) which has lost the neuroendocrine properties characteristic of SCLC.

This work was supported by ACS Grant # PDT-108, NIH Training Grant # 5 T32 CA09072-05, and a gift from the W. W. Smith Foundation.

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Abbreviations

SCLC :

small cell lung cancer

NSCLC :

non-small cell lung cancer

SCLC-V :

small cell lung cancer, variant

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Author information

Authors and Affiliations

  1. Endocrine Oncology, Johns Hopkins University Oncology Center, 600 North Wolfe Street, Baltimore, MD, 21205, USA

    C. A. Griffin & S. B. Baylin

Authors
  1. C. A. Griffin
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  2. S. B. Baylin
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Editor information

Editors and Affiliations

  1. Zentrum für Innere Medizin Medizinische Klinik und Poliklinik Schwerpunkt Hämatologie, Onkologie, Immunologie, Klinikum der Philipps-Universität Marburg, Baldingerstrasse, 3550, Marburg, Deutschland

    Klaus Havemann

  2. Department of Pathology, Dartmouth Medical School, Hanover, NH, 03756, USA

    George Sorenson MD

  3. Klinik Bergisch-Land, Im Saalscheid 5, 5600, Wuppertal-Ronsdorf 21, Deutschland

    Claus Gropp

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© 1985 Springer-Verlag Berlin Heidelberg

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Griffin, C.A., Baylin, S.B. (1985). Oncogene Expression in Human Small Cell Lung Carcinoma. In: Havemann, K., Sorenson, G., Gropp, C. (eds) Peptide Hormones in Lung Cancer. Recent Results in Cancer Research, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82533-0_25

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  • DOI: https://doi.org/10.1007/978-3-642-82533-0_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-15504-1

  • Online ISBN: 978-3-642-82533-0

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