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Regulation of Hormone Production in Small Cell Carcinoma of the Lung

  • G. D. Sorenson
  • C. C. Cate
  • O. S. Pettengill
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 99)

Abstract

Patients with pulmonary carcinoma frequently have elevated levels of one or more circulating tumor-produced hormones. This is particularly characteristic of small cell carcinoma of the lung (SCCL), where an increased frequency of hormone production is seen more commonly than in other types of lung cancer. The most frequently elevated hormones in such patients are calcitonin (CT), ACTH and neurophysins (Sorenson et al. 1984a). In addition to the noteworthy frequency of hormone production by tumors in these patients, there is also a wide variety of hormones produced by individual SCCL tumors. The reasons for the common occurrence and the great variety of hormones produced by SCCL are unknown, as are the molecular mechanisms involved.

Keywords

Small Cell Carcinoma Hormone Production AtT20 Cell Pulmonary Carcinoma Calcitonin Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. D. Sorenson
    • 1
  • C. C. Cate
    • 1
  • O. S. Pettengill
    • 1
  1. 1.Department of PathologyDartmouth Medical SchoolHanoverUSA

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