Peptide Hormone Production in Lung Cancer Cell Lines of Different Histopathological Types
In patients with small cell lung cancer a number of peptide hormone-immunoreactive proteins have been demonstrated by radioimmunoassay (Silva et al. 1974; Berson and Yalow 1966; Horai et al. 1973; Ratcliffe et al. 1982). The small cell carcinoma of the lung is the most common non-endocrine tumor for which an association with the production of a variety of hormones and hormone-immunoreactive proteins has been described (Gropp et al. 1980). In some cases lung tumors of this histological type are associated with paraneoplastic syndromes caused by the peptide hormone production of the tumor. On the basis of these and some other biological characteristics of small cell lung tumors it has been suggested, in particular, that these tumor cells might be derived from pulmonary endocrine cells, the Kultschitzky-like cells in the bronchial submucosa (Skrabanek and Powell 1978; Gazdar et al. 1980). In vivo and in vitro results suggest that the secretion of calcitonin and bombesin is specific for small cell lung tumors (Roos et al. 1980; Silva et al. 1979; Moody et al. 1981). Immunohistological demonstrations of calcitonin and other peptide hormones in small cell as well as in non-small cell lung tumor cells by our group were contradory to this concept (Gropp et al. 1981; Luster et al. 1982).
KeywordsSoft Agar Small Cell Carcinoma Peptide Hormone Large Cell Carcinoma Small Cell Lung Cancer Cell
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