Parathyroid Hormone and PTHmRNA in a Human Small Cell Lung Cancer
Hypercalcemia is often associated with malignant diseases. The frequency of ectopic production of PTH as a cause of humoral hypercalcemia in association with malignant diseases is controversial. Some studies have suggested that patients with tumors and hypercalcemia have elevated iPTH in the serum or in tumor extracts (Sherwood et al. 1967; Benson et al. 1974), whereas others have been unable to detect iPTH in either tumor extracts or serum (Powell et al. 1973). Further studies have shown that humoral hypercalcemia is due to an altered form of PTH, which is unrecognized or only partially recognized by the radioimmunoassay (RIA) for PTH but which is still able to bind to the PTH receptor and is measurable in an in vitro bioassay (Goltzman et al. 1981). Up to now it has not been possible to distinguish between de novo synthesis of PTH by the ectopic tumor cells and the accumulation of exogenous PTH in the tumor tissue.
KeywordsParathyroid Hormone Small Cell Lung Carcinoma Translation Product Tumor Extract Human Small Cell Lung Cancer
Unable to display preview. Download preview PDF.
- Antonavakis SE, Phillips JA III, Mallonee RL, Karzazian HH JR, Fearon ER, Waber PG, Kronenberg HM, Ullrich A, Meyers DA (1983) β-Globin locis is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proc Natl Acad Sci USA 80: 6615–6619.CrossRefGoogle Scholar
- Hehrmann R, Nordmeyer H, Wilke R, Hesch RD (1977) Radioimmunoassay of hPTH; characterisation of two new antisera from sheep and clinical results. Acta Endocrinol (Copenh) [Suppl] 208: 117–118.Google Scholar