Sex Steroid-Binding Protein (SBP)
The sex steroid-binding protein (SBP) of human blood serum binds testerone (T) and estradiol (E2) with high affinity. Discovery and the early investigations in the mid 60ies have been discussed in Vol. I, Chapter XII. The first demonstration was published in 1966 by Rosenbaum (now W. Rosner), Christy, and Kelly. At about the same time, Mercier, Alfsen, and Baulieu found a specific testosterone-binding protein in human serum; a few years later, the identity of the two proteins was recognized. The duality of binding is seen in the name testosterone-estradiol-binding globulin (TeBG) used to this day. Other names are sex steroid-binding β-globulin (SBβG), sex hormone-binding globulin (SHBG), or sex steroid-binding protein (SBP). The abbreviation SBP, introduced by Mercier-Bodard et al. (1970); see Vol. I, p. 524), will be used in this discussion.
KeywordsAmmonium Sulfate Precipitation Equilibrium Dialysis Cyproterone Acetate Hirsute Woman Binding Distribution
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