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Lung Development

  • Chapter
Hormones and Lung Maturation

Part of the book series: Monographs on Endocrinology ((ENDOCRINOLOGY,volume 28))

Abstract

At birth, the major transition for the newborn infant is switching from a passive to an active role in gas exchange. Success in this process is the major determinant of the well-being and survival of newly-born infants. When delivery occurs at term the transition is normally accomplished with ease. With premature delivery, however, the ability of the lung to exchange gas is often inadequate.

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References

  • Adamson IYR, Bowden DH (1974) The type 2 cell as progenitor of alveolar epithelial regeneration. A cytodynamic study in mice after exposure to oxygen. Lab Invest 30: 35

    PubMed  CAS  Google Scholar 

  • Adamson IYR, Bowden DH (1975) Derivation of type 1 epithelium from type 2 cells in the developing rat lung. Lab Invest 32: 736

    PubMed  CAS  Google Scholar 

  • Alescio T, Cassini A (1962) Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 150: 83

    Article  PubMed  CAS  Google Scholar 

  • Avery ME, Mead J (1959) Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 97: 517

    CAS  Google Scholar 

  • Balis JU, Conen PE (1964) The role of alveolar inclusion bodies in developing lung. Lab Invest 13: 1215

    PubMed  CAS  Google Scholar 

  • Benson BJ, Williams MC, Sueishi K, Goerke J, Sargeant T (1984) Role of calcium ions in the structure and function of pulmonary surfactant. Biochim Biophys Acta 793: 18

    PubMed  CAS  Google Scholar 

  • Benson B, Hawgood S, Schilling T, Clements T, Damm D, Cordell B, White RT (1985) Structure of canine pulmonary surfactant apoprotein: cDNA and complete amino acid sequence. Proc Natl Acad Sci USA 82: 6379

    Article  PubMed  CAS  Google Scholar 

  • Beppu OS, Clements JA, Goerke J (1983) Phosphatidylglycerol-deficient lung surfactant has normal properties. J Appl Physiol: Respirat Environ Exercise Physiol 55: 496

    Google Scholar 

  • Bluemink JG, vanMaurik P, Lawson KA (1976) Intimate cell contacts at the epithelial/mesenchymal interface in embryonic mouse lung. J Ultrastr Res 55: 257

    Article  CAS  Google Scholar 

  • Brody JS, Burki R, Kaplan N (1978) Deoxyribonucleic acid synthesis in lung cells during compensatory lung growth after pneumonectomy. Am Rev Resp Dis 117: 307

    PubMed  CAS  Google Scholar 

  • Brody JS, Vaccaro C (1979) Postnatal formation of alveoli: interstitial events and physiologic consequences. Fed Proc 38: 215

    PubMed  CAS  Google Scholar 

  • Brody JS, Kaplan NB (1983) Proliferation of alveolar interstitial cells during postnatal lung growth. Evidence for two distinct populations of pulmonary fibroblasts. Am Rev Respir Dis 127: 763

    Google Scholar 

  • Brumley GW, Chernick V, Hodson WA, Normand C, Fenner A, Avery ME (1967) Correlations of mechanical stability, morphology, pulmonary surfactant, and phospholipid content in the developing lamb lung. J Clin Invest 46: 863

    Article  PubMed  CAS  Google Scholar 

  • Burri PH (1974) The postnatal growth of the rat lung. III. Morphology. Anat Rec 180: 77

    CAS  Google Scholar 

  • Burri PH, Weibel ER (1977) Ultrastructure and morphometry of the developing lung. In: Hodson WA (ed) Lung Biology in Health and Disease, Vol 6, Development of the Lung, Marcel Dekker, New York, pp 215–268

    Google Scholar 

  • Burri PH (1984) Fetal and postnatal development of the lung. Ann Rev Physiol 46: 617

    Article  CAS  Google Scholar 

  • Campiche MA, Gautier A, Hernandez EI, Reymond A (1963) An electron microscope study of the fetal development of human lung. Pediatrics 32: 976

    PubMed  CAS  Google Scholar 

  • Ciba Foundation Symposium 78 (1980) Metabolic Activities of the Lung, Excerpta Medica, New York

    Google Scholar 

  • Clements JA (1957) Surface tension of lung extracts. Soc Exp Biol Med Proc 95: 170

    CAS  Google Scholar 

  • Clements JA, Brown ES, Johnson RP (1958) Pulmonary surface tension and the mucus lining of the lung: some theoretical considerations. J Appl Physiol 12: 262

    PubMed  CAS  Google Scholar 

  • Clements JA, Tierney DF (1965) Alveolar instability associated with altered surface tension. In: Handbook of Physiology, Vol 2, Fenn WO, Rahn H (eds), American Physiological Society, Washington, D.C., pp 1565–1583

    Google Scholar 

  • Clements JA, Nellenbogen J, Trahan HJ (1970) Pulmonary surfactant and evolution of the lungs. Science 169: 603

    Article  PubMed  CAS  Google Scholar 

  • Clements JA, King RJ (1976) Composition of the surface active material. In: The Biochemical Basis of Pulmonary Function, Vol 2, Lung Biology in Health and Disease, Part 4, The Surfactant System of the Lung, Crystal RG (ed), Marcel Dekker, New York, pp 363–387

    Google Scholar 

  • Clements JA, Tooley WH (1977) Kinetics of surface-active material in the fetal lung. In: Lung Biology in Health and Disease, Vol 6, Development of the Lung, Marcel Dekker, New York, pp 349–366

    Google Scholar 

  • Clements JA, Goerke J, Wright JR, Beppo O (1984) Turnover of lung surfactant. Prog Resp Res 18: 133

    CAS  Google Scholar 

  • De Reuck AVS, Porter R (eds) (1967) Ciba Foundation Symposium: Development of the Lung, Little, Brown Company, Boston

    Google Scholar 

  • Evans MJ, Bils RF (1969) Identification of cells labeled with tritiated thymidine in the pulmonary alveolar walls of the mouse. Am Rev Resp Dis 100: 372

    PubMed  CAS  Google Scholar 

  • Evans MJ, Cabral LJ, Stephens RJ, Freeman G (1973) Renewal of alveolar epithelium in the rat following exposure to NO2. Am J Pathol 64: 559

    Google Scholar 

  • Farrell PM (ed) (1982) Lung Development: Biological and Clinical Perspectives, Vol 1, Biochemistry and Physiology, Academic Press, New York

    Google Scholar 

  • Floros J, Phelps DS, Taeusch HW (1985) Biosynthesis and in vitro translation of the major surfactant-associated protein from human lung. J Biol Chem 260: 495

    PubMed  CAS  Google Scholar 

  • Fukuda Y, Ferrans VJ, Crystal RG (1983) The development of alveolar septa in fetal sheep lung. An ui.rastructural and immunohistochemical study. Am J Anat 167: 405

    Google Scholar 

  • Gail DB, Lenfant CJM (1983) Cells of the lung: Biology and clinical implications. Am Rev Resp Dis 127: 366

    Google Scholar 

  • Goerke J (1974) Lung surfactant. Biochim Biophys Acta 344: 241

    PubMed  CAS  Google Scholar 

  • Grant MM, Cutts NR, Brody JS (1983) Alterations in lung basement membrane during fetal growth and type 2 cell development. Develop Biol 97: 173

    Article  PubMed  CAS  Google Scholar 

  • Hage E (1973) The morphological development of the pulmonary epithelium of human foetuses studied by light-and electron microscopy. Z Anat Entwickl-Gesch 140: 271

    Article  CAS  Google Scholar 

  • Hallman M, Kulovich M, Kirkpatrick E, Sugarman GR, Gluck L (1976) Phosphatidylinositol and phosphatidylglycerol in amniotic fluid: indices of lung maturity. Am J Obstet Gynecol 125: 613

    PubMed  CAS  Google Scholar 

  • Hallman M, Gluck L (1976) Phosphatidylglycerol in lung surfactant. III. Possible modifier of surfactant function. J Lipid Res 17: 257

    Google Scholar 

  • Hallman M, Feldman HB, Kirkpatrick E, Gluck L (1977) Absence of phosphatidylglycerol ( PG) in respiratory distress syndrome in the newborn. Pediatr Res 11: 714

    Google Scholar 

  • Hallman M, Enhorning G, Possmayer F (1985) Composition and surface activity of normal and phosphatidylglycerol-deficient lung surfactant. Pediatr Res 19: 286

    Article  PubMed  CAS  Google Scholar 

  • Hawgood S, Benson BJ, Hamilton RL Jr (1985) The effects of a surfactant associated protein and calcium ions on the structure and surface activity of lung surfactant lipids. Biochemistry 24: 184

    Article  PubMed  CAS  Google Scholar 

  • Hodson WA (ed) (1977) Lung Biology in Health and Disease, Vol 6, Development of the Lung, Marcel Dekker, New York

    Google Scholar 

  • Inselman LS, Mellins RB (1981) Growth and development of the lung. J Pediatr 98: 1

    Article  PubMed  CAS  Google Scholar 

  • Kapanci Y, Assimacopoulos A, Irle C, Zwahlen A, Gabbiani G (1974) “Contractile interstitial cells” in pulmonary alveolar septa: A possible regulator of ventilation/perfusion ratio? J Cell Biol 60:375

    Google Scholar 

  • Kapanci Y, Baud M, Mo Costabella P (1983) Alveolar contractile interstitial cells. Their morphology and reactions to hypoxia and to epinephrine stimulation. In: Current problems in Clinical Biochemistry: 13. The Cells of the Alveolar Unit, Favez G, Junod A, Leuenberger P (eds), Hans Huber, Bern, pp 134–141

    Google Scholar 

  • Katyal SL, Singh G (1983) An enzyme-linked immunoassay of surfactant apoproteins. Its application to the study of fetal lung development in the rat. Pediatr Res 17: 439

    Google Scholar 

  • Katyal SL, Singh G (1984) Analysis of pulmonary surfactant apoproteins by isoelectric focusing. Brochim Biophys Acta 194: 411

    Google Scholar 

  • Kauffman SL (1974) Kinetics of alveolar epithelial hyperplasia in lungs of mice exposed to urethane. I. Quantitative analysis of cell populations. Lab Invest 30: 170

    CAS  Google Scholar 

  • Kauffman SL, Burri PH, Weibel ER (1974) The postnatal growth of the rat lung II. Autoradiography. Anat Rec 180: 63

    Google Scholar 

  • Kauffman SL (1977) Acceleration of canalicular development in lungs of fetal mice exposed transplacentally to dexamethasone. Lab Invest 36: 395

    PubMed  CAS  Google Scholar 

  • Kauffman SL (1980) Cell proliferation in the mammalian lung. Int Rev Exp Pathol 22: 131

    PubMed  CAS  Google Scholar 

  • Kikkawa Y, Motoyama EK, Gluck L (1968) Study of the lungs of fetal and newborn rabbits. Ann J Path 52: 177

    CAS  Google Scholar 

  • Kikkawa Y, Spitzer R (1969) Inclusion bodies of type II alveolar cells: Species differences and morphogenesis. Anat Rec 163: 525

    Google Scholar 

  • Kikkawa Y, Kaibara M, Motoyama EK, Orzalesi MM, Cook CD (1971) Morphologic development of fetal rabbit lung and its acceleration with cortisol. Am J Pathol 64: 423

    PubMed  CAS  Google Scholar 

  • King R, Clements JA (1972) Surface active materials from dog lung. II. Composition and physiological correlations. Am J Pathol 223: 715

    Google Scholar 

  • King RJ (1974) The surfactant system of the lung. Fed Proc 33: 2238

    PubMed  CAS  Google Scholar 

  • King RJ, Ruch J, Gikas EG, Platzker ACG, Creasy RK (1975) Appearance of apoproteins of pulmonary surfactant in human amniotic fluid. J Appl Physiol 39: 735

    PubMed  CAS  Google Scholar 

  • King RJ (1982) Pulmonary surfactant. J Appl Physiol: Respirat Environ Exercise Physiol 53: 1

    CAS  Google Scholar 

  • Kotas RV, Farrell PM, Ulane RE, Chez RA (1977) Fetal rhesus monkey lung development: lobar differences and discordances between stability and distensibility. J Appl Physiol: Respirat Environ Exercise Physiol 43:92

    CAS  Google Scholar 

  • Langston C, Kida K, Reed M, Thurlbeck WM (1984) Human lung growth in late gestation and in the neonate. Am Rev Respir Dis 129: 607

    PubMed  CAS  Google Scholar 

  • Maksvytis HJ, Vaccaro C, Brody JS (1981) Isolation and characterization of a lipid-containing interstitial cell from the developing lung. Lab Invest 45: 248

    PubMed  CAS  Google Scholar 

  • Mason RJ (1973) Disaturated lecithin concentration of rabbit tissues. Am Rev Respirat Dis 107: 678

    CAS  Google Scholar 

  • Mason RJ,Williams MC (1977) Type II alveolar cell. Defender of the alveolus. Am Rev Respirat Dis 115 (Suppl): 81

    Google Scholar 

  • Mercurio AR, Rhodin JAG (1977) An electron microscopic study of the type I pneumocyte in the cat: Differentiation. Am J Anat 146: 255

    Google Scholar 

  • Metcalfe IL, Enhorning G, Possmayer F (1980) Pulmonary surfactant-associated proteins: their role in the expression of surface activity. J Appl Physiol: Respirat Environ Exercise Physiol 49: 34

    Google Scholar 

  • Meyrick B,Reid L (1982) Pulmonary arterial and alveolar development in normal postnatal rat lung. Am Rev Respir Dis 125: 468

    Google Scholar 

  • Meyrick B, Reid L (1977) Ultrastructure of alveolar lining and its development. In: Development of the Lung, Hodson WA (ed), Marcel Dekker, New York, pp 135–214

    Google Scholar 

  • Nerurkar LS, Zeligs BJ, Bellanti JA (1977) Maturation of the rabbit alveolar macrophage during animal development. II. Biochemical and enzymatic studies. Pediatr Res 11: 1202

    Google Scholar 

  • Pattie RE (1958) Properties, function and origin of the alveolar lining layer. Proc Roy Soc London, Ser.B 148: 217

    Google Scholar 

  • Reid L (1967) The embryology of the lung. In: Development of the Lung, deReuck AVS, Porter R (eds), Little, Brown and Company, Boston, pp 109–124

    Google Scholar 

  • Robertson B, van Golde LMG, Batenburg JJ (eds) (1984) Pulmonary Surfactant, Elsevier, Amsterdam

    Google Scholar 

  • Sanders RL (1982a) The chemical composition of the lung. In: Lung Development: Biological and Clinical Perspectives, Vol 1, Biochemistry and Physiology, Academic Press, New York, pp 179–192

    Google Scholar 

  • Sanders RL (1982b) The composition of pulmonary surfactant. In: Lung Development: Biological and Clinical Perspectives, Vol 1, Biochemistry and Physiology, Academic Press, New York, pp 193–210

    Google Scholar 

  • Sanders RL (1982c) Major phospholipide in pulmonary surfactant. In: Lung Development: Biological and Clinical Perspectives, Vol 1, Biochemistry and Physiology, Academic Press, New York, pp 211–238

    Google Scholar 

  • Sorokin S, Padykula HA, Herman E (1959) Comparative histochemical patterns in developing mammalian lungs. Dev Biol 1: 125

    Article  CAS  Google Scholar 

  • Sorokin SP (1970) The cells of the lungs. In: Morphology of Experimental Respiratory Carcinogenesis, Nettesheim P, Hanna MG, Deatherage JW Jr (eds), U.S. Atomic Energy Commission Division of Technical Information, pp 3–43

    Google Scholar 

  • Suzuki Y (1966) The structural differentiation of the alveolar lining cells: I. Electron microscopic studies on the prospective alveolar epithelium in the lung tissue of rat embryos. Okaj Fol Anat Jap 42: 119

    CAS  Google Scholar 

  • Ten Have-Opbroek AAW (1981) The development of the lung in mammals: An analysis of concepts and findings. Am J Anat 162: 201

    Article  PubMed  Google Scholar 

  • Tordet C, Marin L, Dameron F (1981) Pulmonary di-and tri-acylglycerols during the perinatal development of the rat. Experimentia 37: 333

    Article  CAS  Google Scholar 

  • Vaccaro C, Brody JS (1979) Ultrastructure of developing alveoli. I. Role of the interstitial fibroblast. Anat Rec 192: 467

    Google Scholar 

  • Von Neergaard K (1929) Neue Auffassungen über einen Grundbegriff der Atemmechanik. Z Ges Exptl Med 66: 373

    Article  Google Scholar 

  • Wang NS,Kotas PV, Avery ME, Thurlbeck WM (1971) Accelerated appearance of osmiophilic bodies in fetal lungs following steroid injection. J Appl Physiol 30: 362

    PubMed  CAS  Google Scholar 

  • Weibel ER, Gil J (1977) Structure-function relationships at the alveolar level. In: Bioengineering Aspects of the Lung, West JB (ed), Marcel Dekker, New York, pp 1–81

    Google Scholar 

  • Wessells NK (1970) Mammalian lung development: Interactions in formation and morphogenesis of tracheal buds. J Exp Zool 175: 455

    Article  PubMed  CAS  Google Scholar 

  • White RT, Damm D, Miller J, Spratt K, Schilling J, Hawgood S, Benson B, Cordell B (1985) Isolation and characterization of the human pulmonary surfactant apoprotein gene. Nature 317: 361

    Article  PubMed  CAS  Google Scholar 

  • Whitsett TA, Hull W, Ross G, Weaver T (1985) characteristics of human surfactant-associated glycoproteins A. Pediatr Res 19: 501

    Google Scholar 

  • Williams MC (1977a) Development of the alveolar structure of the fetal rat in late gestation. Fed Proc 36: 2653

    CAS  Google Scholar 

  • Williams MC (1977b) Conversion of lamellar body membranes into tubular myelin in the alveolar spaces of late fetal rat lung: TEM and HUEM observations. J Cell Biol 72: 260

    Article  CAS  Google Scholar 

  • Williams MC, Benson BJ (1981) Immunocytochemical localization and identification of the major surfactant protein in adult rat lung. J Histochem Cytochem 29: 291

    Article  PubMed  CAS  Google Scholar 

  • Williams MC (1984a) Endocytosis in alveolar type II cells: Effect of charge and size of tracers. Proc Natl Acad Sci USA 81: 6054

    Article  CAS  Google Scholar 

  • Williams MC (1984b) Uptake of lectins by pulmonary alveolar type II cells: Subsequent deposition into lamellar bodies. Proc Natl Acad Sci USA 81: 6383

    Article  CAS  Google Scholar 

  • Zeligs BJ, Nerurkar LS, Bellanti JA (1977a) Maturation of the rabbit alveolar macrophage during animal development. I. Perinatal influx into alveoli and ultrastructural differentiation. Pediatr Res 11: 197

    Article  CAS  Google Scholar 

  • Zeligs BJ, Nerurkar LS, Bellanti JA (1977b) Maturation of the rabbit alveolar macrophage during animal development. III. Phagocytic and bacterial functions. Pediatr Res 11: 1208

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics and Cardiovascular Research Institute, University of California Medical Center, 94143, San Francisco, CA, USA

    Philip L. Ballard M.D., Ph.D. (Professor of Pediatrics)

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  1. Philip L. Ballard M.D., Ph.D.
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© 1986 Springer-Verlag Berlin, Heidelberg

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Ballard, P.L. (1986). Lung Development. In: Hormones and Lung Maturation. Monographs on Endocrinology, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82483-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-82483-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82485-2

  • Online ISBN: 978-3-642-82483-8

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