Abstract
Historically, local regional treatment alone (with surgery or radiation therapy) has been the main approach to the management of patients with newly diagnosed cancer without evidence of distant metastases. Unfortunately, this form of primary therapy alone is not curative for a large number of patients. Failure is felt to be due in large part to the presence of micrometastatic disease that remains undetected at initial diagnosis. Thus, in an effort to destroy these micrometastases, chemotherapy has been introduced as an adjuvant to the primary treatment.
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References
Byar DP (1979) The necessity and justification of randomized clinical trials. In: Tagnon HJ, Staquet MD (eds) Controversies in cancer — design of trials and treatment. Masson, New York
Chalmers TC, Block JB, Lee S (1972) Controlled studies in clinical cancer research. N Engl J Med 297:1091–1096
Freiman JA, Chalmers TC, Smith H, Kuebler RR (1978) The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. N Engl J Med 299:690–694
Ludwig Breast Cancer Study Group (1981) Study V: protocol for perioperative and conventionally-timed chemotherapy in operable breast cancer. Activated: 13 november 1981; revised: may and november 1982. Ludwig Institute for Cancer Research, Bern
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1976) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer 34:585–612
Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1–39
Sackett DL, Gent M (1979) Controversy in counting and attributing events in clinical trials. N Engl J Med 301:1410–1414
Stanley K, Stjernsward J, Isley M (1981) The conduct of a cooperative clinical trial. Springer Berlin Heidelberg New York. (recent results in cancer research, vol 77)
Zelen M (1983) Guidelines for publishing papers on cancer clinical trials: responsibilities of editors and authors. J Clin Oncol 1:164–169
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Gelber, R.D. (1985). Methodological and Statistical Aspects in Perioperative Chemotherapy Trials. In: Metzger, U., Largiadèr, F., Senn, HJ. (eds) Perioperative Chemotherapy. Recent Results in Cancer Research, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82432-6_7
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DOI: https://doi.org/10.1007/978-3-642-82432-6_7
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