Abstract
Perioperative chemotherapy is increasing in use and importance, as is indicated by the very fact of this conference. Its use is designed to achieve cure in a larger number of patients than can be cured by surgery alone. Patients now receive chemotherapy or radiotherapy either before surgical resection, to improve the results of standard treatment or to increase the possibility of removal of large lesions, or following surgery, to remove any microscopic remnants of tumor following resection.
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References
Ahonen J (1968) Nucleic acids in experimental granuloma. Acta Physiol Scand [Suppl] 315:1–73
Alrich EM, Carter JP, Lehman EP (1951) The effect of ACTH and cortisone on wound healing. Ann Surg 133:783–789
Archer RR, Greenwell EJ, Ware T, Weeks PM (1970) Irradiation effect on wound healing in rats. Radiat Res 41:104–112
Ariyan S, Kraft RL, Goldberg NH (1980a) An experimental model to determine the effects of adjuvant therapy on the incidence of postoperative wound infection: II. Evaluating preoperative chemotherapy. Plast Reconstr Surg 65:338–345
Ariyan S, Marfuggi RA, Harder G, Goodie MM (1980b) An experimental model to determine the effects of adjuvant therapy on the incidence of postoperative wound infection: I. Evaluating preoperative radiation therapy. Plast Reconstr Surg 65:328–337
Arumugam S, Nimmannit S, Enquist IF (1971) The effect of immunosuppression on wound healing. Surg Gynecol Obstet 133:72–74
Bains JW, Crawford DT, Ketcham AS (1966) Effect of chronic anemia on wound tensile strength: correlation with blood volume, total red blood cell volume and proteins. Ann Surg 164:243–246
Barham RE, Butz GW, Ansell JS (1978) Comparison of wound strength in normal, radiated and infected tissues closed with polyglycolic acid and chromic catgut sutures. Surg Gynecol Obstet 146:901–907
Bartlett MK, Jones CM, Ryan AE (1942a) Vitamin C and wound healing I. Experimental wounds in guinea pigs. N Engl J Med 226:469–473
Bartlett MK, Jones CM, Ryan AE (1942b) Vitamin C and wound healing II. Ascorbic acid content and tensile strength of healing wounds in human beings. N Engl J Med 226:474–481
Belli JA, Piro AJ (1977) The interaction between radiation and Adriamycin damage in mammalian cells. Cancer Res 37:1624–1630
Billingham RE, Russell PS (1956) Studies on wound healing, with special reference to the phenomenon of contracture in experimental wounds in rabbits’ skin. Ann Surg 144:961–981
Bole GG, Heath LE (1967) The effect of 6-mercaptopurine on the inflammatory response stimulated by subcutaneous implantation of polyvinyl sponge. Arthritis Rheum 10:377–387
Boucek RJ, Noble NL (1955) Connective tissue: a technique for its isolation and study. Arch Pathol 59:553–558
Burr HS, Harvey SC, Taffel M (1938) Bio-electric correlates of wound healing. Yale J Biol Med 11:103–107
Calnan J, Davies A (1965) The effect of methotrexate (Amethopterin) on wound healing: an experimental study. Br J Cancer 19:505–512
Casey WJ, Peacock EE Jr, Chvapil M (1976) Induction of collagen synthesis in rats by transplantation of allogenic macrophages. Surg Forum 27:53–55
Clark RA, Stone RD, Leung DYK, Silver I, Hohn DC, Hunt TK (1976) Role of macrophages in wound healing. Surg Forum 27:16–18
Cohen SC, Gabelnick HL, Johnson RK, Goldin A (1975a) Effects of antineoplastic agents on wound healing in mice. Surgery 78:238–244
Cohen SC, Gabemick HL, Johnson RK, Goldin A (1975b) Effects of cyclophosphamide and Adriamycin on the healing of surgical wounds in mice. Cancer 36:1277–1281
Conn JH, Leb SM, Hardy JD (1957) Effect of nitrogen mustard and thio-TEPA on wound healing. Surg Forum 8:80–83
Cuthbertson DP (1954) Interrelationship of metabolic changes consequent to injury. Br Med Bull 10:33–37
Daly JM, Vars HM, Dudrick SJ (1972) Effects of protein depletion on strength of colonic anastomoses. Surg Gynecol Obstet 134:15–21
Desprez JD, Kiehn CL (1960) The effects of cytoxan (cyclophosphamide) on wound healing. Plast Reconstr Surg 26:301–308
Devereux DF, Thibault L, Boretos J, Brennan MF (1979a) The quantitative and qualitative impairment of wound healing by Adriamycin. Cancer 43:932–938
Devereux DF, Thistlethwaite PA, Thibault LE, Brennan MF (1979b) Effects of tumor bearing and protein depletion on wound breaking strength in the rat. J Surg Res 27:233–238
Devereux DF, Kent H, Brennan MF (1980a) Time dependent effects of Adriamycin and X-ray therapy on wound healing in the rat. Cancer 45:2805–2810
Devereux DF, Thibault L, Brennan MF (1980b) Effects of tumor removal on wound breaking strength in rats. Surg Forum 31:234–236
Devereux DF, Triche TJ, Webber BL, Thibault LE, Brennan MF (1980c) A study of Adriamycin-reduced wound breaking strength in rats: an evaluation by light and electron microscopy, induction of collagen maturation, and hydroxyproline content. Cancer 45:2811–2815
Diegelmann RF, Cohen IK, Kaplan AM (1981) The role of macrophages in wound repair: a review. Plast Reconstr Surg 68:107–113
DiPasquale G, Steinetz BG (1964) Relationship of food intake to the effect of cortisone acetate on skin wound healing. Proc Soc Exp Biol Med 117:118–121
Dobbs WGH (1939) A statistical study of the effect of roentgen rays on wound healing. AJR 41:625–632
Dunphy JE, Jackson DS (1962) Practical applications of experimental studies in the care of the primarily closed wound. Am J Surg 104:273–282
Dunphy JE, Udupa KN (1955) Chemical and histochemical sequences in the normal healing of wounds. N Engl J Med 253:847–851
Edwards LC, Pernokas LN, Dunphy JE (1957) The use of a plastic sponge to sample regenerating tissue in healing wounds. Surg Gynecol Obstet 105:303–309
Ehrlich HP, Hunt TK (1968) Effects of cortisone and vitamin A on wound healing. Ann Surg 169:324–328
Ehrlich HP, Hunt TK (1969) The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg 170:203–206
Ehrlich HP, Tarver H, Hunt TK (1963) Effects of vitamin A and glucocorticoids upon inflammation and collagen synthesis. Ann Surg 177:222–227
Farhat SM, Amer NS, Weeks DS, Musselman MM (1958) Effect of mechlorethamine hydrochloride (nitrogen mustard) on healing of abdominal wounds. Arch Surg 76:749–753
Farhat SM, Miller DM, Musselman MM (1959) Effect of triethylenethiophosphoramide (Thio-TEPA) upon healing of abdominal wounds. Arch Surg 78:729–731
Findlay CW Jr, Howes EL (1952) The combined effect of cortisone and partial protein depletion on wound healing. N Engl J Med 246:597–604
Fu KK (1979) Normal tissue effects of combined radiotherapy and chemotherapy for head and neck cancer. Front Radiat Ther Oncol 13:113–132
Grillo HC (1963) Origin of fibroblasts in wound healing: an autoradiographic study of inhibition of cellular proliferation by local X-irradiation. Ann Surg 157:453–467
Grillo HC, Potsaid MS (1961) Studies in wound healing: IV. retardation of contraction by local X-irradiation, and observations relating to the origin of fibroblasts in repair. Ann Surg 154:741–750
Gupta RC, Singh LM, Udupa KN (1970) Effect of cyclophosphamide (Endoxan) on the process of wound healing. Indian J Surg 32:127–132
Hardesty WH (1958) The effect of cytotoxic drugs on wound healing in rats. Cancer Res 18:581–584
Hatiboglu I, Moore GE, Wilkens HJ, Hoffmeister F (1960) Effects of chemotherapeutic agents on wounds contaminated with tumor cells: an experimental study. Ann Surg 152:559–567
Heite VHJ, Irro H (1973) Ablauf der wundheilung unter anwendung anaboler und kataboler steroide am kaninchenohr-modell nach Heite. Arzneimittelforsch 23:1341–1346
Heughan C, Grislis G, Hunt TK (1974) The effect of anemia on wound healing. Ann Surg 179:163–167
Howes EL, Sooy JW, Harvey SC (1929) The healing of wounds as determined by their tensile strength. JAMA 92:42–45
Howes EL, Ploth CM, Blunt JW, Ragan C (1950) Retardation of wound healing by cortisone. Surgery 28:177–181
Hugo NE, Thompson LW, Zook EG, Bennett JE (1969) Effect of chronic anemia on the tensile strength of healing wounds. Surgery 66:741–745
Hunt TK, Pai MP (1972) The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet 135:561–567
Hunt TK, Ehrlich HP, Garcia JA, Dunphy JE (1969) Effect of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man. Ann Surg 170:633–641
Jacobson MJ, Prohaska JV (1965) The healing of wounds in iron deficiency. Surgery 57:254–258
Juva K (1968) Hydroxylation of proline in the biosynthesis of collagen. Acta Physiol Scand [Suppl] 308:1–73
Kitagawa T, Glicksman AS, Tyree EB, Nickson JJ (1961) Radiation effects on skin and subcutaneous tissue. A quantitative study of collagen content: modification with L-triiodothyronine. Radiat Res 15:761–766
Kraft RL, Goldberg NH, Ariyan S (1979) Effect of preoperative high-dose methotrexate and leucovorin rescue on incidence of wound infection in rats. Surg Forum 30:537–539
Lawrence W Jr, Nickson JJ, Washaw LM (1953) Roentgen rays and wound healing. An experimental study. Surgery 33:376–384
Leibovich SJ, Ross R (1975) The role of the macrophage in wound repair: a study with hydrocortisone and antimacrophage serum. Am J Pathol 78:71–99
Lenco W, McKnight M, MacDonald AS (1975) Effects of cortisone acetate, methylprednisolone and medroxyprogesterone on wound contracture and epithelization in rabbits. Ann Surg 181:67–73
Levenson SM, Crowley LV, Geever EF, Rosen H, Berard CW (1964) Some studies of wound healing: experimental methods, effect of ascorbic acid and effect of deuterium oxide. J Trauma 4:543–566
Levenson SM, Geever EF, Crowley LV, Oates JF III, Berard CW, Rosen H (1965) The healing of rat skin wounds. Ann Surg 161:293–308
Macon WL, Pories WJ (1971) The effect of iron deficiency anemia on wound healing. Surgery 69:792–796
Madden JW, Peacock EE Jr (1967) Measurement of the rate of collagen synthesis in sutured rat wounds. Surg Forum 18:56–57
Madden JW, Peacock EE Jr (1968) Studies on the biology of collagen during wound healing. I. Rate of collagen synthesis and deposition in cutaneous wounds of the rat. Surgery 64:288–294
Madden JW, Peacock EE Jr (1971) Studies on the biology of collagen during wound healing: III. Dynamic metabolism of scar collagen and remodeling of dermal wounds. Ann Surg 174:511–520
Madden JW, Smith HC (1970) The rate of collagen synthesis and deposition in dehisced and resutured wounds. Surg Gynecol Obstet 130:487–493
Meadows EC, Prudden JF (1953) A study of the influence of adrenal steroids on the strength of healing wounds. Surgery 33:841–848
Moore FD, Brennan MF (1975) Surgical injury: body composition, protein metabolism, and neuroendocrinology. In: Ballinger WF, Collins JA, Drucker WR, Dudrick SJ, Zeppa R (eds) Manual of surgical nutrition. Saunders, Philadelphia, pp 172–173
Morris T, Lincoln F, Lee A (1978) The effect of 5-fluorouracil on abdominal wound healing in rats. Aust NZ J Surg 48:219–221
Mullen BM, Mattox DE, Von Hoff DD, Hearne EM (1981) The effect of preoperative adriamycin and dihydroxyanthracenedione on wound healing. Laryngoscope 91:1436–1443
Murphy K, Frith C, Lang N, Westbrook KC (1980) Effect of radiotherapy on healing of colonic anastomoses. Surg Forum 31:222–223
Nathanson IT (1934) The effect of the gamma-ray of radium on wound healing. Surg Gynecol Obstet 59:62–69
Niinikoski J (1969) Effect of oxygen supply on wound healing and formation of experimental granulation tissue. Acta Physiol Scand [Suppl] 334:7
Niinikoski J, Hunt TK, Dunphy JE (1972) Oxygen supply in healing tissue. Am J Surg 123:247–252
Paolucci R, Zanoni F, Azzarelli A (1975) L’azione della chemioterapia sui processi di cicatrizzazione. Tumori 61:441–446
Pearce CW, Foot NC, Jordan GL Jr, Law SW, Wantz GE Jr (1960) The effect and interrelation of testosterone, cortisone, and protein nutrition on wound healing. Surg Gynecol Obstet 111:274–284
Phillips TL, Fu KK (1976) Quantification of combined radiation therapy and chemotherapy effects on critical normal tissues. Cancer 37:1186–1200
Pisesky W, Williams HTG, MacKenzie WC (1959) The effect of triethylene thiophosphoramide (ThioTEPA) and 17-ethyl-19-nortestosterone (Nilevar) on wound healing. Can J Surg 2:291–294
Pohle EA, Ritchie G (1933) Studies of the effect of roentgen rays on the healing of wounds II. Histological changes in skin wounds in rats following postoperative irradiation. Radiology 20:102–108
Pohle EA, Ritchie G, Wright CS (1931) Studies of the effect of roentgen rays on the healing of wounds I. The behavior of skin wounds in rats under pre- or post-operative irradiation. Radiology 16:445–460
Polverini PJ, Cotran RS, Gimbrone MA Jr, Unanue ER (1977) Activated macrophages induce vascular proliferation. Nature 269:804–806
Porter RR (1977) Structure and activation of early components of complement. Fed Proc 36:2191–2196
Rath H, Enquist IF (1959) The effect of Thio-TEPA on wound healing. Arch Surg 79:812–814
Remensnyder JP, Majno G (1968) Oxygen gradients in healing wounds. Am J Pathol 52:301–323
Ritchie G (1933) Effect of roentgen irradiation on the nealing of wounds. Arch Pathol 16:839–851
Rosenberrry TL, Richardson JM (1977) Structure of 18S and 14S acetylcholinesterase. Identification of collagen-like subunits that are linked by disulfide bonds to catalytic subunits. Biochemistry 16:3550–3558
Ross R, Benditt EP (1962) Wound healing and collagen formation II. Fine structure in experimental scurvy. J Cell Biol 12:533–551
Ross R, Bornstein P (1969) The elastic fiber I. The separation and partial characterization of its macromolecular components. J Cell Biol 40:366–381
Rudolph R, Utley J, Woodward M, Hum I (1981) The ultrastructure of chronic radiation damage in rat skin. Surg Gynecol Obstet 152:171–178
Salmela K, Ahonen J (1981) The effect of methylprednisolone and vitamin A on wound healing. Acta Chir Scand 147:307–312
Sandberg N (1964) Time relationship between administration of cortisone and wound healing in rats. Acta Chir Scand 127:446–455
Sandberg N, Zederfeldt B (1959) Influence of acute hemorrhage on wound healing in the rabbit. Acta Chir Scand 118:367–371
Sandberg N, Zederfeldt B (1963) The tensile strength of healing wounds and collagen formation in rats and rabbits. Acta Chir Scand 126:187–196
Savlov ED, Dunphy JE, Anderson MA (1954) The healing of the disrupted and resutured wound. Surgery 36:362–370
Seifter E, Rettura G, Padawer J, Stratford F, Kambosos D, Levenon SM (1981) Impaired wound healing in streptozotocin diabetes. Prevention by supplemental vitamin A. Ann Surg 194:42–50
Simpson DM, Ross R (1972) The neutrophilic leukocyte in wound repair. A study with antineutrophil serum. J Clin Invest 51:2009–2023
Spain DM, Molomut N, Haber A (1950) Biological studies on cortison in mice. Science 112:335–337
Stajie J, Milovanovic A (1970) Radiation and wound healing: evolution of tensile strength in excised skin-wound of irradiated rats. Strahlentherapie 139:87–90
Staley CJ, Trippel OH, Preston FW (1961) Influence of 5-fluorouracil on wound healing. Surgery 49:450–453
Stein JM, Levenson SM (1966) Effect of the inflammatory reaction on subsequent wound healing. Surg Forum 17:484–485
Stephens FO, Hunt TK (1971) Effect of changes in inspired oxygen and carbon dioxide tensions on wound tensile strength: an experimental study. Ann Surg 173:515–519
Stratford F, Seifter E, Rettura G, Babyatsky M, Levenson SM (1980) Impaired wound healing due to cyclophosphamide alleviated by supplemental vitamin A. Surg Forum 31:224–225
Taylor FW, Dittmer TL, Porter DO (1952) Wound healing and the steroids. Surgery 31:683–690
Thakral KK, Goodson WH III, Hunt TK (1979) Stimulation of wound blood vessel growth by wound macrophages. J Surg Res 26:430–436
Udenfriend S (1966) Formation of hydroxyproline in collagen. Science 152:1335–1340
Viljanto J (1964) Biochemical basis of tensile strength in wound healing. Acta Chir Scand [Suppl] 333:1–91
Vogel HG (1970) Tensile strength of skin wounds in rats after treatment with corticosteroids. Acta Endocrinol 64:295–303
Wie H, Bruaset I, Eckersberg T (1979) Effects of cyclophosphamide an open granulating skin wounds in rats. Acta Pathol Microbiol Scand [A] 87:185–192
Wiener SL, Urivetsky M, Isenberg HD, Havier R, Wiener R, Belenko M, Heydu E, Meilman E (1976) Fibroblast DNA synthesis activation in sponge induced granulation tissue: the effect of antineutrophil serum and cyclophosphamide. Connect Tissue Res 4:223–235
Wiener SL, Urivetsky M, Isenberg HD, Belenko M, Talansky A, Havier R, Meilman E (1977) Activation of prolyl hydroxylase in sponge induced granulation tissue: the effect of antineutrophil serum and inhibitor drugs. Connect Tissue Res 5:97–108
Wiznitzer T, Orda R, Bawnik JB, Rippin A, Griffel B, Herzberg M (1973) Mitomycin and the healing of intestinal anastomosis: an experimental study in the rat. Arch Surg 106:314–316
Yonemasu K, Stroud RM, Niedermeier W, Butler WT (1971) Chemical studies on Clq; A modulator of immunoglobulin biology. Biochem Biophys Res Commun 43:1388–1394
Zelman D, Song IC, Porteous DD, Bromberg BE (1969) The effect of total body irradiation on wound healing and the hematopoietic system in mice. Bull NY Acad Med 45:293–300
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Shamberger, R. (1985). Effect of Chemotherapy and Radiotherapy on Wound Healing: Experimental Studies. In: Metzger, U., Largiadèr, F., Senn, HJ. (eds) Perioperative Chemotherapy. Recent Results in Cancer Research, vol 98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82432-6_3
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