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Surgical Intervention and Metastasis

  • R. Keller
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 98)

Abstract

It is now appreciated that the tumor-host relationship is intimate and complex, and that the outcome of tumor disease depends on many variables pertaining to both host and tumor. This implies that each tumor-host relationship has individual features; accordingly, there are few valid general conclusions to be drawn from the immense effort focused on this problem. Despite these reservations it is possible to identify certain major issues that are applicable in a variety of clinical and experimental situations. As some of these issues may well be relevant to the establishment of more appropriate therapeutic regimens they are briefly outlined here. The experimental examples were derived from the D-12 rat fibrosarcoma, a model studied extensively in this laboratory (Keller 1980, 1981, to be published).

Keywords

Primary Tumor Disseminate Tumor Cell Viable Tumor Cell Spontaneous Metastasis Metastatic Tumor Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Butler TP, Gullino PM (1975) Qantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res 35:512–516PubMedGoogle Scholar
  2. Carr I, Carr J (1980) Experimental lymphatic invasion and metastasis. In: Weiss L, Gilbert HA, Ballon SC (eds) Lymphatic system metastasis. Hall, Boston, pp 41–73Google Scholar
  3. Fidler IJ (1976) Patterns of tumor cell arrest and development. In: Weiss L (ed) Fundamental aspects of metastasis. North-Holland, Amsterdam, pp 275–289Google Scholar
  4. Fidler IJ (1978) General considerations for studies of experimental cancer metastasis. Methods Cancer Res 15:399–439Google Scholar
  5. Fidler IJ, Kripke ML (1977) Metastasis results from pre-existing variant cells within a malignant tumor. Science 197:893–895PubMedCrossRefGoogle Scholar
  6. Gorelik E (1982) Antimetastatic concomitant immunity. In: Liotta LA, Hart IR (eds) Tumor invasion and metastasis. Nijhoff, The Hague, pp 113–131CrossRefGoogle Scholar
  7. Hart IR, Fidler IJ (1981) The implication of tumor heterogeneity for studies in the biology and therapy of cancer metastasis. Biochim Biophys Acta 651:37–50PubMedCrossRefGoogle Scholar
  8. Keller R (1980) Distinctive characteristics of host tumor resistance in a rat fibrosarcoma model system. In: van Furth R (ed) Mononuclear phagocytes. Functional aspects. Nijhoff, The Hague, pp 1725–1740Google Scholar
  9. Keller R (1981) Induction of macroscopic metastases via surgery. The site of the primary tumor inoculum is critical. Invasion and Metastasis 1:136–148Google Scholar
  10. Keller R (to be published) Elicitation of macroscopic metastases via surgery: various forms of surgical intervention differ in their induction of metastatic outgrowthGoogle Scholar
  11. Keller R, Hess MW (1982) Divergency between incidence of microscopic and macroscopic metastases. Virchows Arch A 398:33–43CrossRefGoogle Scholar
  12. Ketcham AS, Kinsey DL, Wexler H, Mantel N (1961) The development of spontaneous metastases after the removal of the primary tumor. Cancer 14:875–881PubMedCrossRefGoogle Scholar
  13. Kinsey DL (1961) Effects of surgery upon cancer metastasis. JAMA 178:734–735PubMedCrossRefGoogle Scholar
  14. Kleinerman J, Liotta L (1977) Release of tumor cells. In: Day SB, Stansly P, Laird Myers SP, Garattini S, Lewis MG (eds) Cancer invasion and metastasis: biologic mechanisms and therapy. Raven, New York, pp 135–143Google Scholar
  15. Kodama T (1977) Pathology of immunologic regression of tumor metastases in the lymph nodes. Gann Monogr Cancer Res 20:83–91Google Scholar
  16. Kurokawa Y (1970) Experiments on lymph node metastasis by intralymphatic inoculation of rat ascites tumor cells, with special reference to lodgement, passage, and growth of tumor cells in lymph nodes. Gan 61:461–471PubMedGoogle Scholar
  17. Lewis MR, Cole WH (1958) Experimental increase in lung metastases after operative trauma. Arch Surg 77:621–626CrossRefGoogle Scholar
  18. Mitchell MS (1980) A note on the lymph node as an immunologic barrier. In: Weiss L, Gilbert HA, Ballon SC (eds) Lymphatic system metastasis. Hall, Boston, pp 74–79Google Scholar
  19. Nicolson GL (1982) Cancer metastasis: organ colonization and the cell surface properties of malignant cells. Biochim Biophys Acta 695:113–176PubMedGoogle Scholar
  20. Poste G (1982) Experimental systems for analysis of the malignant phenotype. Cancer Metast Rev 1:141–199CrossRefGoogle Scholar
  21. Roos R, Dingemans KP (1980) Mechanisms of metastasis. Biochim Biophys Acta 650:135–166Google Scholar
  22. Schatten WE (1958) An experimental study of postoperative tumor metastases. I. Growth of pulmonary metastases following total removal of primary leg tumor. Cancer 11:455–459PubMedCrossRefGoogle Scholar
  23. Simpson-Herren L, Sanford AH, Holmquist JP (1976) Effects of surgery on the cell kinetics of residual tumor. Cancer Treat Rep 60:1749–1760PubMedGoogle Scholar
  24. Sugarbaker EV (1979) Cancer metastasis: a product of tumor-host interactions. Curr Probl Cancer 7:1–59CrossRefGoogle Scholar
  25. Sugarbaker EV, Ketcham A (1977) Mechanisms and prevention of cancer dissemination: an overview. Semin Oncol 4:19–32PubMedGoogle Scholar
  26. Sugarbaker EV, Thornthwaite J, Ketcham AS (1977) Inhibitory effect of a primary tumor on metastasis. In: Day SB, Stansly P, Laird Myers WP, Garattini S, Lewis MG (eds) Cancer invasion and metastasis: biologic mechanisms and therapy. Raven, New York, pp 227–240Google Scholar
  27. Sugarbaker EV, Weingrad DN, Roseman JM (1982) Observations on cancer metastasis in man. In: Liotta LA, Hart IR (eds) Tumor invasion and metastasis. Nijhoff, The Hague, pp 427–465CrossRefGoogle Scholar
  28. Tyzzer EE (1913) Factors in the production and growth of tumor metastases. J Med Res 28:309–312PubMedGoogle Scholar
  29. Weiss L (1977) A pathologic overview of metastasis. Semin Oncol 4:5–17PubMedGoogle Scholar
  30. Weiss L (1979) Dynamic aspects of cancer cell populations in metastasis. Am J Pathol 97:601–608PubMedGoogle Scholar
  31. Weiss L (1980) The pathophysiology of metastasis within the lymphatic system. In: Weiss L, Gilbert HA, Ballon SC (eds) Lymphatic system metastasis. Hall, Boston, pp 2–40Google Scholar
  32. Willis RA (1973) The spread of tumours in the human body, 3rd edn. Butterworths, LondonGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. Keller
    • 1
  1. 1.Institut für Immunologie und VirologieUniversität Zürich, Arbeitsgruppe für ImmunbiologieZürichSwitzerland

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