Clinical Experience with Preoperative Chemotherapy for Osteosarcoma
Since 1978, patients with osteosarcomas have been treated with preoperative chemotherapy (Cserhati et al. 1981). As an additional and important part of our bone sarcoma studies in Zurich, we transplant specimens obtained at the initial biopsy and at the resection after chemotherapy into nude mice for additional evaluation (Groscurth et al. 1982). Several experimental essays for chemosensitivity testing are then performed, as has been outlined elsewhere (Hofmann et al. 1983). An essential and important part is the evaluation by conventional histological analysis and the measurement of necrotic changes in the resected tumors. Our technique for assessment of necrosis has been described elsewhere (Von Hochstetter et al. 1981).
KeywordsPreoperative Chemotherapy Chemotherapy Protocol Historical Group Necrotic Change Additional Chemotherapy
Unable to display preview. Download preview PDF.
- Cserhati M, Honegger HP, von Hochstetter A, Groscurth P, Hofmann V (1983) Zurich bone sarcome study I. Concepts of the clinical, morphological and functional study. In: Verhandlungen der deutschen Krebsgesellschaft, Vol 4, Fischer, Stuttgart, p 782Google Scholar
- Groscurth P, Hofmann V, Cserhati M, von Hochstetter A, Honegger HP (1982) Xenogeneic transplantation and in vitro cultivation of human osteosarcomas after preoperative chemotherapy. Proceedings of the 13th international cancer congress, Sept 13. Abstract 2159, p 379Google Scholar
- Honegger HP, von Hochstetter A, Groscurth P, Hofmann V, Cserhati M (1984) The effect of chemotherapy on human bone sarcomas: a clinical and experimental study. In: Hofmann V, Berens ME, Martz G (eds) Predictive drug testing on human tumor cells. Springer, Berlin Heidelberg New York Tokyo, p 65. In: Recent results in cancer research, Vol 94CrossRefGoogle Scholar
- Rosen G, Caparros B, Nirenberg A. Cisplatinum-adriamycin combination chemotherapy in evaluable osteogenic sarcoma. Proc Am Soc Clin Oncol 1:173 (abstract C-672)Google Scholar