Clinical Experience with Preoperative Chemotherapy for Osteosarcoma
Since 1978, patients with osteosarcomas have been treated with preoperative chemotherapy (Cserhati et al. 1981). As an additional and important part of our bone sarcoma studies in Zurich, we transplant specimens obtained at the initial biopsy and at the resection after chemotherapy into nude mice for additional evaluation (Groscurth et al. 1982). Several experimental essays for chemosensitivity testing are then performed, as has been outlined elsewhere (Hofmann et al. 1983). An essential and important part is the evaluation by conventional histological analysis and the measurement of necrotic changes in the resected tumors. Our technique for assessment of necrosis has been described elsewhere (Von Hochstetter et al. 1981).
KeywordsHydration Sarcoma Methotrexate Cyclophosphamide Osteosarcoma
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