Sufentanil: A Synthetic Narcotic for Total Intravenous Anaesthesia?
High-dose fentanyl anaesthesia has been reported to suppress or at least attenuate the increases in stress hormones associated with surgical stimulation (Sebel et al. 1981; Stanley et al. 1980). Sufentanil, a potent analogue of fentanyl, has more affinity for opiate receptors (Stahl et al. 1977) and a higher therapeutic index (De Castro et al. 1979), and thus may be more efficacious in blocking these hormonal responses. A recent study (Bovill et al. 1983) demonstrated that sufentanil in a dose of 15 μg/kg could not block the hormonal increases which occurred during cardiopulmonary bypass. This study was undertaken to compare the hormonal response to these drugs in the clinical setting.
KeywordsCatheter Attenuation Cortisol Norepinephrine Epinephrine
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